reproductive facts

Question 1

estrogen reproductive effects

Answer 1

controls proliferation of the endometrium
acts via nuclear estrogen receptors alpha and beta to change transcription

Question 2

Progesterone

Answer 2

Controls later part of the secretory phase

Question 3

Estrogen vasoactive effects

Answer 3

acts Via GPCR (GPR30 or GPER)
Stimulates nitric oxide synthase

Question 4

Combined pill action

Answer 4

estrogen inhibits FSH via negative feedback to pituitary
Progestogen inhibits LH and ovulation
———
-contraception
——-
-Thromboembolism

Question 5

Progestogen only

Answer 5

Taken all the time with no breaks
-good for people now get BP increase
-changes mucus to be inhospitable
-changes fallopian tube motility
——
-contraception
——
-irregular menstruation
-less contraception reliability

Question 6

Levonorgestrel

Answer 6

Plan B
-effective for 72 hours intercourse
-can take gravol for nausea

Question 7

Oxytocin

Answer 7

/
Enhance uterine motility by stimulating contraction via Ca+ influx
——–
-stimulates contraction for birth
——–
-hypotension
-high doses increase contraction duration which can starve placenta and baby of O2

Question 8

Ergometrine

Answer 8

/
may act on alpha adrenoreceptors or 5-HT to stimulate uterus contraction from a relaxed state (no effect on contracted uterus)
——-
-stimulate contractions
——–
-Vomiting

Question 9

Mifepristone

Answer 9

Progesterone receptor competitive inhibitor
-used to induce abortion
——–
-abortion
-used with a prostaglandin analog
——–

Question 10

Misoprostol

Answer 10

Prostaglandin analog
-ripens the cervix and induce contraction
——–
-abortion
-use with mifepristone lowers dose
———

Question 11

Gemeprost

Answer 11

Prostaglandin analog
-ripens the cervix and induce contraction
——–
-abortion
-use with mifepristone lowers dose
———

Question 12

atosiban

Answer 12

oxytocin receptor competitive antagonist
-delays labour by preventing the Ca+ influx
-also prevents oxytocin release of prostaglandins
——–
-inhibit uterine motility

Question 13

Salbutamol

Answer 13

/
beta receptors can inhibit the oxytocin induced contractions
———–
-inhibit uterine motility
———

Question 14

Clomiphene

Answer 14

/
estrogen antagonist on pituitary reducing negative feedback increasing FSH and LH release
——-
-infertility
——
-flushing
-vaginal dryness
-bone loss
-reversible ovarian enlargement

Question 15

Gonadorelin

Answer 15

synthetic GnRH increasing FSH and LH release
-given in pulses
——–
-infertility
-stimulate ovulation for egg collection
——–
-flushing
-vaginal dryness
-bone loss

Question 16

Sildenafil

Answer 16

/
-PDE 5 inhibitor causing increased cGMP and NO increase
——–
-erectile dysfunction
———
-hypotension
-visual disturbances from PDE 6 inhibition