Antimycobacterials facts Flashcards
1
Q
mycobacteria cell wall
A
peptidoglycan, arabinogalactan, mycolic acid
does not retain violet stain but is not Gram negative
2
Q
Tb treatment
A
Isoniazid, rifampicin, pyrazineamide and maybe ethambutol for 2 months
Then isoniazid and rifampicin for 4m
3
Q
Leprosy treatment
A
Tuberculoid, dapsone rifampicin 6m
lepromatous, dapsone, rifampicin and clofazimine F2Y
4
Q
Isoniazid activation
A
prodrug activated by katG which prevents mycolic acid synthesis
5
Q
isoniazid admin
A
do not take with food
6
Q
Rifampicin admin
A
do not take with food
7
Q
Pyrazinamide selectivity
A
is only bacterial static at acidic pH like in lysosomes
