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Pharmaceutics II Exam 2 > Specific Transdermal Products > Flashcards

Specific Transdermal Products Flashcards

1
Q

what products are available for transdermal testosterone?

A

testoderm and androderm (brand names)

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2
Q

between testoderm and androderm - determine which is membrane and which is matrix type

A

matrix type = testoderm
membrane type = androderm

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3
Q

explain in detail the components of testoderm

A

matrix type 3-layer patch

-backing layer of PET
-matrix film layer of testosterone
-adhesive strips of polyisobutylene, colloidal silicone dioxide

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4
Q

differentiate between where the patch is placed between androderm and testoderm

A

testoderm - patch is placed on scrotum to treat testosterone deficiency (DONT NEED PERMEATION ENHANCER)

androderm - patch is placed on back, abdomen, upper arms, or thighs – MAINLY CHEST (NEED PERMEATION ENHANCER)

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5
Q

Explain in detail the contents of androderm patch

A

five layer, membrane type patch

-backing film of ethylene-vinyl acetate copolymer, polyester laminate

-reservoir of testosterone, alcohol, glycerin, glyceryl monooleate, methyl laurate felled with acrylic acid copolymer

-microporous polyethylene membrane

-acrylic adhesive

-adhesive polyester laminate

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6
Q

name the transdermal products that are for PREVENTION and not treatment

A

transdermal nitroglycerin and transdermal scopolamine

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7
Q

what is the brand name for transdermal scopolamine

A

Transderm Scop

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8
Q

is Transderm Scop membrane or matrix type

A

membrane

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9
Q

explain how Transderm Scop is used

A

there is continuous release of the drug over THREE DAYS to PREVENT nausea and vomiting from motion sickness

the patch is placed behind the ear

for repeated administration, the first patch is removed and 2nd patch placed behind the other ear

also approved to PREVENT nausea of certain anashetics/analgesics used in surgery

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10
Q

explain the design of transderm scop

A

4 layer, membrane type patch

-backing layer of aluminized polyester film
-reservoir of scopolamine, mineral oil, polyisobutylene
-microporous polypropylene membrane (for rate control)
-adhesive of polyisobutylene, mineral oil, scopolamine

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11
Q

true or false

scopolamine is for the treatment of nausea and vomiting due to motion sickness

A

FALSE - for prevention, not treatment

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12
Q

what are the brand name products of transdermal nitroglycerin

A

deponit
nitro-dur
transderm-nitro

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13
Q

state the 3 transdermal nitroglycerin products and whether they are membrane or matrix type

A

Deponit - matrix
Nitro-dur - matrix
transderm-nitro - membrane type

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14
Q

explain the design of Deponit

A

three layer, matrix type system

-covering foil (ensure unidirection)
-nitroglycerin matrix with adhesive, plasticizer
-protective foil (removed before use)

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15
Q

what is the function of a plasticizer

A

increases surface area so polymer can spread

used in Deponit in 2nd layer

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16
Q

explain the design of Nitro-Dur

A

5-layer, matrix type patch

nitroglycerin in gel-like matrix of glycerin water, lactose, PVA, povidone, sodium citrate sealed in polyester, foil, polyethylene laminate

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17
Q

explain the contents of transderm-nitro

A

4-layer, membrane type system

-backing layer
-reservoir of nitroglycerin
-ethylene-vinyl acetate copolymer membrane
-silicone adhesive

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18
Q

transdermal nitroglycerin is a _____ hour patch

A

24

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19
Q

what is the brand name for transdermal clonidine

A

Catapres-TSS (clonidine transdermal therapeutic system)

20
Q

is catapres-TTS matrix or membrane type? how many layers is it? what is the generic?

A

generic = transdermal clonidine
membrane type
4 layers

21
Q

explain the design of Catapres-TTS

A

-backing of pigmented polyester film
-reservoir of clonidine
-microporous polypropylene membrane
-adhesive

22
Q

explain how Catapres-TTS is applied and what it’s used for

A

antihypertensive – delivered at a constant rate for 7 DAYS

generally applied to hairless or shaven area of the UPPER ARM or TORSO

23
Q

explain the lack of control that exists with Catapres-TTS

A

not that easy to control because the delivery is over 7 days and we can’t really control the day by day release

24
Q

of the transdermal patches mentioned in this chapter, which 3 are most popular

A

scopolamine
nitroglycerin
nicotine

25
Q

name a transdermal patch that is not used for treatment (but not prevention really either)

A

NICOTINE

26
Q

name all the brand names of transdermal nicotine

A

Habitrol
NicoDerm
Nicotrol
Prostep

27
Q

determine whether all the brand names of transdermal nicotine are matrix or membrane type

A

Habitrol - matrix
Nicotrol - matrix
Prostep - matrix
Nicoderm - membrane

28
Q

between all the brand names of transdermal nicotine, which are round patches and which are rectangular?

A

round - Habitrol, prostep

rectangle - nicoderm, nicotrol

29
Q

who manufactures nicoderm and nicotrol?

A

GSK

30
Q

GO BACK TO CONTENTS

A

GO BACK

31
Q

name the brand names of transdermal estradiol

A

Estraderm
Vivelle
Climara

32
Q

name the brand names of transdermal estradiol and state whether they are membrane or matrix type

A

membrane - Estraderm

matrix - Vivelle, Climara

33
Q

explain how estraderm is applied

A

releases 17Beta estradiol continuously, patch is applied to trunk (including abdomen and buttocks) at ALTERNATING SITES, TWICE WEEKLY OVER A 3 WEEK CYCLE with dosage frequency being adjusted as required

34
Q

explain how Vivelle is used

A

same as estroderm

35
Q

explain how Climara is used

A

similar to Estroderm, but the system may be applied WEEKLY instead of twice weekly over a 3 day period

36
Q

of the brand transdermal estradiols, name the # of layers in each

A

estraderm - 4 layer
vivelle - 3 layer
climara - 3 layer

37
Q

of the brand transdermal estradiol, which contain(s) a separate adhesive layer?

A

Estraderm is the only one

other 2 (vivelle and climara) have adhesive contained in the matrix

38
Q

what is the component of the rate controlling membrane that is frequently used in transdermal patches?

A

EVA (ethylene-vinyl acetate copolymer membrane)

39
Q

go back to estradiol components

A

go back

40
Q

what is the brand name for transdermal fentanyl

A

Duragesic

41
Q

is Duragesic membrane or matrix type

A

membrane

42
Q

as a general rule, which usually require a separate adhesive layer - membrane or matrix type?

A

membrane

43
Q

explain how long Duragesic can be used and why it is used

A

continuous 72 hour SYSTEMIC delivery of potent opioid analgesic (10x more potent than morphine) in pts with chronic pain requiring opioids

44
Q

what is the onset time of Duragesic

A

VERY FAST

the silicone adhesive contains fentanyl which allows for immediate release for those with extreme pain

45
Q

explain the components of Duragesic

A

4-layer, membrane type system

-backing layer of polyester film
-reservoir of fentanyl, alcohol gelled with hydroxyethyl cellulose
-rate controlling ethylene-vinyl acetate copolymer membrane
-fentanyl containing silicone adhesive

46
Q
A

Pharmaceutics II Exam 2 (7 decks)

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