Adrenal gland + disorders Flashcards
1
Q
Order of investigations for Cushing’s disease? (1 through 5)
A
- 24hr urinary free cortisol
- AM + PM serum cortisols
- Overnight dexamethasone suppression test
- Serum ACTH (low = adrenal, high = pituitary)
- Petrosal sinus sampling
2
Q
Zona glomerulosa makes?
A
Aldosterone (outer cortex)
GFR is ACE
3
Q
Zona fasciculata makes?
A
Cortisol (middle)
GFR is ACE
4
Q
Zona reticularis makes?
A
Sex steroids (most inner layer of capsule) GFR is ACE
5
Q
What does the adrenal medulla make?
A
adrenaline
6
Q
Electrolyte findings with adrenal insufficiency?
A
Dec Na, Inc K, Dec BSL
7
Q
Most common type of CAH?
A
21OH def (90%)
Females: genital hypertrophy
Males: salt losing crisis (Inc Na, Dec K)
8
Q
Physiological problem in 5-alpha reductase?
A
Can’t make testosterone into DHT
9
Q
Clinical findings on exam in 5-alpha reductase?
A
Micropenis or bifid scrotum
