Bio Final pt2 Flashcards
What are the four major structures that compose a neuron?
Dendrite, soma, axon, and presynaptic terminal
What kind of glial cell wraps around the synaptic terminals of axons?
Astrocytes
Which chemicals cross the BBB passively?
Uncharged molecules
- Oxygen, CO2, H20
- Fat soluble chemicals
Which chemicals cross the BBB by active transport? (6)
Glucose, amino acids, purines, choline, certain vitamins, iron
Santiago Ramon y Cajal were responsible for what discovery?
The nervous system is composed of separate cells
Which part of a neuron has its own genes, separate from those of the nucleus?
Mitochondria
What is most distinctive about neurons compared to other cells?
Their shape
What do dendritic spines do?
They increase the surface area available for synapses
What does an efferent axon do?
It carries output from a structure
What do astrocytes do?
Synchronize activity for a group of neruons
What does the microglia do?
Microglia removes dead cells and weak synapses
Which of these can easily cross the BBB?
- Fat-soluble molecules
- Chemotherapy drugs
- Proteins
- Viruses
A
What is the brain’s main source of fuel?
Glucose
For the brain to use its main source of fuel, what does it also need?
Thiamine
When the membrane is at rest, are the sodium ions more concentrated inside the cell or outside? Where are the potassium ions more concentrated?
Sodium ions are more concentrated outside the cell.
Potassium ions are more concentrated inside the cell
When the membrane is at rest, what tends to drive the potassium ions out of the cell? What tends to draw them into the cell?
The concentration gradient drives potassium out of the cell.
Electrical gradient and sodium-potassium pump draws them into the cell.
What is the difference between a hyperpolarization and a depolarization?
Hyperpolarization - a more negative level than usual. Exaggeration of the usual negative charge within the cell
Depolarization is a decrease in the amount of negative charge within the cell
What happens if the depolarization does or does not reach the threshold?
If it passes the threshold it produces an action potential.
If it does not pass threshold there are no action potentials
Does the all or none law apply to dendrites? Why or why not?
Does not apply to dendrites because they do not have action potentials
During the rise of the action potential, do sodium ions move into the cell or out of it? Why?
Move into the cell. Sodium is attracted to the inside of the cell by both an electrical and a concentration gradient
As the membrane reaches the peak of the action potential, what brings the membrane down to the original resting potential?
The potassium ions exit the cell, driving the membrane back to the resting potential
In a myelinated axon, how would the action potential be affected if the nodes were much closer together? How might it be affected if the nodes were much father apart?
If the nodes were closer the action potential would be slower. If they were further apart they would be faster.
If they are too far apart the action potential can’t reach so it would stop.
Under what conditions does an axon produce an action potential?
Whenever the membrane’s potential reaches the threshold
If a membrane is depolarized to twice its threshold, what happens?
The neuron produces the same action potential it would at the threshold
To which part or parts of a neuron does the all-or-none law apply?
Axons
During the rising portion of the action potential, which ions are moving across the membrane and in which direction?
Sodium ions move in
After the action potential reaches its peak, the potential across the membrane falls toward its resting level. What accounts for this recovery?
Potassium ions move out because their channels re open and the concentration gradient pushing them out
What does the myelin sheath of an axon accomplish?
It enable action potentials to travel more rapidly
What causes the refractory period of an axon?
The sodium channels are closed
What is the difference between temporal summation and spatial summation?
Temporal summation is the combined effect of quickly repeated stimulation at a sign synapse
Spatial summation is the combined effect of several nearly simultaneous stimulations at several synapses onto one neuron
What ion gates in the membrane open during an EPSP? What gates open during an IPSP?
During EPSP, sodium gates open
IPSP potassium or chloride gates open
Can an inhibitory message flow along an axon?
No, only action potentials propagate along an axon. Inhibitory messages -IPSPs- decay over time and distance
According to Sherrington, why do the extensor muscles of a leg relax when the flexor muscles contract?
Inhibitory connections in the spinal cord
In what way were Sherrington’s conclusions important for psychology as well as neuroscience?
He demonstrated the importance of inhibition
What was Loewi’s evidence that neurotransmission depends on the release of chemicals?
Frogs heart rate
Blood flow increases to the most active brain areas. How does the blood know which areas are the most active?
In a highly active brain area, many stimulated neurons release nitric oxide, which dilates the blood vessels in the area and thereby makes it easier for blood to flow to the area
Name the three catecholamine neurotransmitters.
Epinephrine
Norepinephrine
Dopamine
When the action potential reaches the presynaptic terminal, which ion must enter the presynaptic terminal to evoke the release of the neurotransmitter?
Calcium
How do ionotropic and metabotropic synapses differ in speed and duration of effects?
Ionotropic synapses act more quickly and more briefly
How do LSD, nicotine, and opiate drugs influence behavior?
LSD binds to one type of serotonin receptor. Nicotine binds to one type of acetylcholine receptor, Opiates bind to endorphin receptors
How do amphetamine and cocaine influence synapses?
They block reuptake of released dopamine, serotonin and norepinephrine
Why is methylphenidate generally less disruptive to behavior than cocaine is despite the drugs’ similar mechanisms?
It develops and declines in the brain much more slowly than do those of cocaine
How do cannabinoids affect neurons?
They inhibit further release of both glutamate and GABA
Which of the following is not one of the brain’s neurotransmitters?
- Glutamate
- GABA
- Glucose
- Serotonin
C
Which of these is not a catecholamine?
- Serotonin
- Dopamine
- Norepinephrine
- Acetylcholine
D
Suppose you want to cause the presynaptic terminal of an axon to release its transmitter. How could you do so without an action potential?
Inject calcium into the presynaptic terminal
Which type of synapse is better suited for vision and hearing, and why?
Ionotropic synapses because they produce quick, brief effects
What is the most abundant excitatory ionotropic neurotransmitter?
Glutamate
What process is the serotonin transporter responsible for?
Reuptake
Except for the magnitude and speed of effects, methylphenidate (Ritalin) affects synapses the same way as which other drug?
Cocaine
In what way do cannabinoids differ from other drugs that affect the nervous system?
Cannabinoids act on the presynaptic neuron
What does ventral mean, and what is its opposite?
Ventral means toward the stomach side.
Opposite is dorsal
What term means toward the midline, and what is its opposite?
Midline is medial
Opposite is lateral
The bulges in the cerebral cortex are called ___. The grooves between them are called___.
Gyri; sucli
Motor nerves leave from which side of the spinal cord, dorsal or ventral
Ventral
Which functions are controlled by the sympathetic nervous system?
Fight or flight response
What makes up the hindbrain? (3)
Cerebellum, medulla, and pons
What makes up the forebrain? (5)
Basal Ganglia
Hippocampus
Hypothalamus
Pituitary
Thalamus
Which area is the main source of input to the cerebral cortex?
Thalamus
If two structures are both on the left side, or both on the right, what is their relationship?
Ipsilateral
What is the function of the dorsal roots of the spinal cord?
They receive sensory input
Which of these controls breathing, heart rate, and salivation?
- Hippocampus
- Cranial Nerves
- Basal Ganglia
- Pituitary gland
Cranial Nerves
What do the ventricles contain?
Cerebrospinal fluid
If several neurons of the visual cortex all respond best when the retina is exposed to horizontal lines of light, then those neurons are probably in the same
Column
Which lobe of the cerebral cortex includes the primary auditory cortex?
Temporal
Which lobe includes the primary somatosensory cortex?
Parietal
Which lobe includes the primary visual cortex?
Occipital
Which lobe includes the primary motor cortex?
Frontal
What are the functions of the prefrontal cortex?
-Movement
- Working memory, cognitive control, and emotion
- Decision making
What is the main way in which mammalian species vary in their cerebral cortex?
Brains differ in their size and degree of folding
What is the relationship between columns and laminae in the cerebral cortex?
Each column crosses through one lamina after another
What is the binding problem?
The question of how we perceive separate sensations as part of a single object
What is the difference between a lesion and an ablation?
A lesion is a damage to a structure.
Ablation is the removal of a structure
What does fMRI measure?
Increase in blood flow to a brain area
What are the similarities and differences between MRI and fMRI?
Both measure the responses of brain chemicals to a magnetic field. MRI shows the anatomy of the brain. fMRI shows which brain areas are most active at the moment
What does the ontogenetic technique enable researchers to test?
The function of a particular type of neuron
EEG and MEG are advantageous for measuring what?
Changes in brain activity over very short periods of time
How does a sex-linked gene differ from a sex-limited gene?
A sex-linked gene icon the X or Y chromosome. A sex-limited gene is on an autosomal chromosome, but activated in one sex more than the other.
How does an epigenetic change differ from a mutation?
A mutation is a permanent change in part of a chromosome.
An epigenetic change is an increase or decrease in the activity of a gene or group of genes
What does micro deletion remove?
Part of a chromosome
What is the difference between monozygotic (MZ) and dizygotic (DZ) twins?
MZ twins develop from a single egg, whereas DZ twins develop from two eggs
Why do human infants show a grasp reflex?
The reflex was advantageous to infants of our remote ancestors
Which comes first: migration, synaptogenesis, or myelination?
Migration
New receptor neurons form in which sensory system?
Olfaction
What was Sperry’s evidence that axons grow to a specific target instead of attaching at random?
If he cut a newt’s eye and inverted, axons grew back to their original targets, even though the connections were inappropriate to their new positions on the eye
What process assures that the spinal cord has the right number of axons to innervate all the muscle cells?
The nervous system builds more neurons than it needs and discards through apoptosis those that do not make lasting synapses
What class of chemicals prevents apoptosis in the sympathetic nervous system?
Neurotrophins, such as nerve growth factor
At what age does a person have the greatest number of neurons- early in life, during adolescence, or during adulthood?
Early in life
Which brain area shows expanded representation of the left hand in people who began practicing stringed instruments in childhood and continued for many years?
Somatosensory cortex (postcentral gyrus) of the right hemisphere
Why is immaturity of the prefrontal cortex not a satisfactory explanation for risky behaviors in adolescents?
As the teenage years progress, risky behavior tends to increase, even though the prefrontal cortex is becoming more mature
In early brain development, what is the relationship between the sensory systems and muscle movements?
The first muscle movements occur before the sensory systems develop
Is collateral sprouting a change in axons or dendrite receptors?
Axons
is denervation supersensitivity a change in axons or dendritic receptors?
Dendritic receptors
What are the two kinds of stroke, and what causes each kind?
Ischemia: Result of an occlusion of an artery.
Hemorrhage: Result of a ruptured artery
Why is tPA not helpful in cases of hemorrhage?
tPA breaks up blood clots, and hemorrhage results from a ruptured blood vessel, not a blood clot