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FINALS-PEDIA > ENDOCRINE QUIZ > Flashcards

ENDOCRINE QUIZ Flashcards

1
Q

This gene is considered the prophet of PIT

A. PTX 2
B. POU1F1
C. PROP1
D. POU1F2

A

C. PROP1

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2
Q

It is the most common recessive form of Multiple Pituitary Hormone Deficiency (MPHD).

A. Mutations in PTX2
B. Mutations in PROP1
C. Mutations in POU1F1
D. Mutations in POU1F2

A

B. Mutations in PROP1

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3
Q

It is a nuclear protein that binds to the GH and PRL promoters

A. LHX3
B. PTX2
C. PROP1
D. POU1F1

A

D. POU1F1

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4
Q

GH1 gene is one of a cluster of 5 genes on this chromosome.

A. Chr 17q22-24
B. Chr 17q21-23
C. Chr 17q22-25
D. Chr. 17q21-24

A

A. Chr 17q22-24

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5
Q

The definitive diagnosis of growth
hormone deficiency is the demonstration of:

A. High levels of IGF1
B. High levels of GH
C. Low levels of GH
D. Low levels of IGF1

A

C. Low levels of GH

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6
Q

The maximum of days of estrogen priming needed prior to GH testing to achieve greater diagnostic specificity is:

A. 2 days
B. 3 days
C. 4 days
D. 5 days

A

B. 3 days

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7
Q

It is the hormone involved in Diabetes
Insipidus.

A. Desmopressin
B. Pitressin
C. Vasopressin
D. ACTH

A

C. Vasopressin

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8
Q

Extracellular fluid volume is regulated by this mechanism.

A. K intake and secretion
B. K intake and excretion
C. Na intake and secretion
D. Na intake and excretion

A

D. Na intake and excretion

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9
Q

Vasopressin release is stimulated by this process:

A. Dec in plasma tonicity
B. Inc in plasma tonicity
C. Dec in urine volume
D. Inc in urine volume

A

B. Inc in plasma tonicity

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10
Q

The diagnosis of diabetes insipidus is
established when:

A. Serum osmolality is > 200, urine
osmolality is < 200
B. Serum osmolality is > 300, urine
osmolality is > 300
C. Serum osmolality is < 200, urine
osmolality is > 200
D. Serum osmolality is >300, urine
osmolality is < 300

A

D. Serum osmolality is >300, urine
osmolality is < 300

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11
Q

This results in defects in the aquaporin-2 gene.

A. Congenital autosomal recessive NDI
B. Congenital autosomal dominant NDI
C. Congenital X-linked NDI
D. Congenital hypopituitarism

A

A. Congenital autosomal recessive NDI

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12
Q

Atrial natriuretic peptide (ANP) has a
number of effects on salt and water
balance such as:

A. Inhibition of natriuresis
B. Inhibition of Na resorption
C. Inhibition of K resorption
D. Stimulation of vasopressin
secretion

A

B. Inhibition of Na resorption

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13
Q

A water deprivation test is indicated when pathologic polyurua and polydipsia are president and serum osmolality is:

A. >250mOsm/kg, < 300mOsm/kg

B. >260mOsm/kg, < 300mOsm/kg

C. > 270mOsm/kg, < 300mOsm/kg

D. >270mOsm/kg, >300mOsm/kg

A

C.
>270mOsm/kg, < 300mOsm/kg

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14
Q

Mutations in this gene cause septo-optic dysplasia:

A. HESX1
B. LHX3
C. LHX4
D. PTX

A

A. HESX1

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15
Q

The gene that is also referred as RIEG1 is called:

A. PTX1
B. PTX2
C. LHX3
D. LHX4

A

B. PTX2

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16
Q

When a person consumes more than 2L per day, he would have increased urine output and the serum Na would be:

A. Normal
B. Dec
C. Inc
D. Absent

A

B. Dec

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17
Q

A persons with hypotonic fluid overload would have a serum Na of:

A. < 125 meq/L
B. < 130 meq/L
C. < 135 meq/L
D. < 140 meq/L

A

C. < 135 meq/L

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18
Q

Rapid correction of a person with serum of 115 meq/L will cause:

A. Lateral pontine myelinosis
B. Cerebral salt wasting
C. Central cerebellar myelinolysis
D. Central pontine myelinolysis

A

D. Central pontine myelinolysis

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19
Q

The gold standard for diagnosis of tall
stature is:

A. MRI
B. IV glucose challenge test
C. IGF-1 challenge test
D. Oral Glucose challenge test

A

D. Oral Glucose challenge test

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20
Q

A syndrome characterized by large
tongue, pancreatic B-cell hyperplasia,
enlarged liver is:

A. Reiger syndrome
B. Beckwith-weidmann syndrome
C. McCune albright syndrome
D. Sotos syndrome

A

B. Beckwith-weidmann syndrome

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21
Q

This gene turns on POUF1 expression and is called the prophet of PIT1

A. PROP1
B. PROP2
C. PTX1
D. PROP

A

A. PROP1

22
Q

This syndrome is caused by mutations in the PTX2 transcription gene.

A. Hall-Pallister syndrome
B. Hypogammaglobulinemia
C. Reiger syndrome
D. Ritter’s syndrome

A

C. Reiger syndrome

23
Q

The most common cause for recessive
multiple pituitary hormone deficiency is mutations of this gene:

A. HESX1
B. LHX3
C. PTX2
D. PROP1

A

D. PROP1

24
Q

This gene is expressed in precursor cell of all 5 cell types of the early embryologic development of the pituitary gland.

A. LHX3
B. LHX4
C. HESX1
D. PTX2

A

C. HESX1

25
Q

It is nuclear protein that binds to the
growth hormone and prolactin promoters

A. PTX2
B. PTX3
C. PIT1
D. PROP1

A

C. PIT1

26
Q

The GH1 gene is one of a cluster of 5 genes on chromosome

A. 17q 21-24
B. 17q 22-24
C. 17q 23-25
D. 17q 22-24

A

D. 17q 22-24

27
Q

The half life of vasopressin in the
circulation is:

A. 3 minutes
B. 4 minutes
C. 5 minutes
D. 6 minutes

A

C. 5 minutes

28
Q

It is a 9-aminopeptide antidiuretic and has vascular pressor activity synthesized in the hypothalamus.

A. Desmopressin
B. Vasopressin
C. Pitressin
D. dDAVP

A

B. Vasopressin

29
Q

A 10-year old obese has polyuria,
polydipsia and hyperpigmentation of the skin and back sought consult. FBS is high at 190pmg/dL with high insulin levels. Your most likely diagnosis is:

A. Type 1 DM
B. Type 2 DM
C. Cushing’s syndrome
D. Hypercortisolism

A

B. Type 2 DM

30
Q

Congenital X-linked Nephrogenic Diabetes Insipidus (NDI) results from mutations in gene/recptor:

A. Aquaporin-1 gene
B. Aquaporin-2 gene
C. Vasopressin V1 receptor
D. Vasopressin V2 receptor

A

D. Vasopressin V2 receptor

31
Q

Congenital autosomal recessive NDI
results from mutations in:

A. Aquaporin-1 gene
B. Aquaporin-2 gene
C. Vasopressin V1 receptor
D. Vasopressin V2 receptor

A

B. Aquaporin-2 gene

32
Q

In systemic dehydration, the intravascular volume characterized as:

A. Low
B. Normal
C. High
D. Very high

A

A. Low

33
Q

In cerebral salt wasting, vasopressin level is characterized as:

A. Low
B. Normal
C. High
D. Very high

A

A. Low

34
Q

It is an autosomal dominant connective
tissue disorder characterized by increased arm span.

A. Klinefelter syndrome
B. XYY syndrome
C. Marfan syndrome
D. Turners syndrome

A

C. Marfan syndrome

35
Q

The most common brain lesion causing
true precocious puberty is:

A. Prolactinoma
B. Craniopharyngioma
C. Hypothalamic hamartomas
D. Corticoprolactinoma

A

C. Hypothalamic hamartomas

36
Q

The most common cause of infants who are large for gestational age is:

A. Maternal Diabetes Mellitus
B. Weaver syndrome
C. Hyperthyroidism
D. Cerebral gigantism

A

A. Maternal Diabetes Mellitus

37
Q

An autosomal recessive inborn error of
amino acid metabolism causing mental
retardation and resembles Marfan
syndrome is:

A. SHOX excess syndromes
B. Weaver syndrome
C. Homocystinuria
D. Fragile X syndrome

A

C. Homocystinuria

38
Q

The cardinal clinical feature of gigantism includes:

A. Longitudinal growth acceleration
B. Coarse facial features
C. Enlarging hands and feet
D. Visual problems

A

A. Longitudinal growth acceleration

39
Q

In young persons with open epiphysis,
overproduction of growth hormone
results in:

A. Acromegaly
B. Gigantism
C. Klinefelter syndrome
D. Sotos syndrome

A

B. Gigantism

40
Q

The most common tumors of the pituitary in adolescents are:

A. Corticoprolactinoma
B. Prolactinoma
C. Corticotropinomas
D. Craniopharyngiomas

A

B. Prolactinoma

41
Q

The most common adenomas seen
prepubertally are:

A. Corticoprolactinoma
B. Prolactinoma
C. Corticotropinomas
D. Craniopharyngiomas

A

B. Prolactinoma

42
Q

The following are TRUE of Type 1 Diabetes Mellitus, EXCEPT:

A. Due damage to pancreativc B cells
B. Also called juvenile diabetes
C. Development of ketoacidosis is
frequent
D. Occurs predominantly in adults

A

D. Occurs predominantly in adults

43
Q

The following statements are TRUE about Type 2 Diabetes Mellitus, EXCEPT:

A. Non-insulin dependent diabetes
B. Noted peripheral insulin
resistance
C. With absolute insulin deficiency
D. non-autoimmune destruction of B
cells

A

C. With absolute insulin deficiency

44
Q

This is the end result of metabolic
abnormalities from a severe insulin
deficiency or insulin effectiveness.

A. Hyperglycemia
B. Ketoacidosis
C. Metabolic alkalosis
D. Pheochromocytoma

A

B. Ketoacidosis

45
Q

This is the major cause of morbidity and mortality in children with Type 1 Diabetes mellitus.

A. Ketoacidosis
B. Cerebral edema
C. Hyperglycemia
D. Nonketotic Hyperosmolar coma

A

B. Cerebral edema

46
Q

A well 11-year old female sought consult due to short stature. Family history showed a few short maternal aunts. which is the most likely test that will help you with your diagnosis?

A. Bone aging
B. Thyroid hormone tests
C. Serum cortisol levels
D. Serum insulin levels

A

A. Bone aging

47
Q

Syndrome of inappropriate antidiuretic
hormone secretion is characterized by
hyponatremia and an inappropriately
concentrated urine mOsm/kg value of:

A. > 100
B. > 200
C. > 300
D. > 400

A

A. > 100

48
Q

Infants with congenital defects of the
pituitary and hypothalamus usually
present with the following characteristics, EXCEPT:

A. Apnea
B. Cyanosis
C. Jaundice
D. Hyperglycemia

A

D. Hyperglycemia

49
Q

Chronic SIADH is BEST treated with one of the following:

A. Diuretics
B. Oral fluid restriction
C. Demeclocycline
D. Sodium supplementation

A

B. Oral fluid restriction

50
Q

The classic manifestations of polyuria,
polydipsia, optic atrophy, and brain
abnormalities characterize this disorder

A. Hyponatremia
B. Diabetes insipidus
C. Cerebral salt wasting
D. Syndrome of Inappropriate
Antidiuretic Hormone

A

B. Diabetes insipidus

FINALS-PEDIA (16 decks)

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