Cell wall and folic acid inhibitors facts

Question 1

dihydropteroate synthetase

Answer 1

DHPS, enzyme needed in folic acid synthesis blocked by sulfonamides

Question 2

Folate antagonists

Answer 2

They mimic the pteridine moiety of folate and inhibit bacterial dihydrofolate, reductase (DHFR)

Question 3

Beta lactams

Answer 3

irreversible inhibitors of penicillin binding proteins PBPs
Prevents peptidoglycan synthesis

Question 4

beta-lactamase

Answer 4

enzyme made by bacteria to hydrolyze ring

Question 5

Prototype beta-lactams

Answer 5

Penicillin G and V
lactamase sensitive

Question 6

Narrow spec beta-lactams

Answer 6

Methicillin, cloxacillin, oxacillin
lactamase resistant

Question 7

Broad spec beta-lactams

Answer 7

Ampicillin, amoxicillin
lactamase sensitive

Question 8

extended spec

Answer 8

Piperacillin, Ticarcillin
lactamase sensitive

Question 9

penicillin excretion

Answer 9

90% eliminated via renal tubules

Question 10

Cephalosporin generations

Answer 10

-Increase in lactamase resistance
-Increase to negative spec
-increase in BBB penetration
-3 and 4 lose gram positive spec

Question 11

Transglycosylase and transpeptidase

Answer 11

cross link NAM and NAG