lecture 5 - bone growth + joint tissue Flashcards
What do bones begin as?
Cartilage models
What are cartilage models made of?
Hyaline
What is the name of the process of turning cartilage models into bone?
Endochondral ossification
What type of cartilage cells excrete cartilage matrix in the cartilage model initially?
Chondrocytes
What role to the blood vessels that develop around the cartilage model serve?
They supply fibroblasts, which differentiate into osteoblasts, which build bone.
What is the first bone structure formed in a developing bone?
A superifical layer of bone on the diaphysis under the periosteum - a ‘collar’ of bone
Where is the primary ossification centre of long bones?
In the diaphysis.
When blood vessels penetrate the centre of the developing bone, what occurs?
Osteoblasts produce cancellous/spongy bone in the shaft of the long bone.
What does remodelling in the developing bone create?
A medullary cavity.
How are the secondary ossification centres formed?
Capilalries and osteoblasts migrate into the ephysises.
What is intersitital growth?
The lengthening of the diaphysis/bone shaft, which takes place at the metaphysis.
What is the metaphysis?
The narrowed area that seperates the diaphysis from the epiphysis.
What seperates the spongy bone of the epiphysis from the diaphysis, during development?
The epiphyseal plate/growth plate
What is the epiphyseal plate?
A layer of cartilage that seperates the epiphysis of a bone from the diaphysis, allowing the diaphysis to grow in length.
What happens when bone size is at its maximum and epiphyseal plate disappears?
An epiphyseal closure will be formed by osteoblasts.
Do soft joint tissues have inorganic components?
No
What is the overall structure of cartilage?
Collagen fibres in a ground substance. Chondrocytes in lake like lacunae.
Does cartilage have blood supply?
No
How do nutrients reach cartilage cells?
By diffusing through the matrix via joint loading as pressure is applied to the joint