Protein structure

Question 1

peptide bond

Answer 1

condensation reaction. covalend bond between the hydroxy and amino groups of. flat plane. only movement is 2 twists at either side of alpha carbon

Question 2

protein structure heirarchy

Answer 2

primary
secondary
tertiary
quaternary

Question 3

Primary protien structure

Answer 3

purely the chain of amino acids, no structure. only the order of amino acids

Question 4

Secondary protein structure

Answer 4

beta sheet and alpha helic. local folding. folding at the alpha carbons, not the R groups yet. hydrogen bonds. (also random coil)

Question 5

Tertiary protein structure

Answer 5

final shape of protein. ionic and hydrophobic affect (get hydophobic residues in centre of protein)

Question 6

Quaternary

Answer 6

multiple proteins come together to form a larger system
homologous: same subunits
heterologous: different subunits

Question 7

maintaining shape

Answer 7

hydrogen bonds
hydrophobic interactions: oil like side chains that don’t like water
ionic interactions
disulfide bonds:
post translational modifications
zinc finger motiff
chaperone proteins that help folding

Question 8

zinc finger

Answer 8

small local fold with a zinc ion, stabilised by cysteine and histidine. extra force to hold some proteins together

Question 9

Domains for proteins

Answer 9

a section of a protein that does something and can be present in multiple different proteins

Question 10

what is a protein

Answer 10

a ribosome synthesised polypeptide chain of amino acids (and other elements/modifications), that under certain solvent conditions, performs functions according to its 3D structure