Odontogenic Tumours Flashcards

1
Q

What are the 3 groups that odontogenic tumours can be classified into

A
  • epithelial
  • mesenchymal
  • mixed
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2
Q

What are the main 3 epithelial tumours

A

 Ameloblastoma
 Adenomatoid odontogenic tumour
 Calcifying epithelial odontogenic tumour

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3
Q

What is the main mesenchymal tumour

A

Odontogenic myxoma

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4
Q

What is the main mixed tumour

A

Odontoma (aka odontome)

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5
Q

What are the odontogenic sources of epithelium

A

rests of mallasez
rests/glands of serres
reduced enamel epithelium

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6
Q

What is the rest of mallasez a remnant of

A

hertwig’s epithelial root sheat

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7
Q

What is the rests/glands of Serres a remnant of

A

the dental lamina

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8
Q

What is the reduced enamel epithelium a remnant of

A

These are remnants of the enamel organ

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9
Q

What is the growth pace of ameloblastoma

A

slow

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10
Q

What are the symptoms of ameloblastoma

A

Painless
Can be locally destructive however

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11
Q

How common is ameloblastoma

A

1% of oral and maxfax tumours

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12
Q

What is the most common age for ameloblastoma

A

30-60 yrs old

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13
Q

What is the most common location for ameloblastoma

A

Posterior mandible

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14
Q

What gender is ameloblastoma more common in

A

males

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15
Q

What are the radiological types of ameloblastoma

A

multicystic
unicystic (less common)

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16
Q

What population is unicystic lesions more common in

A

younger px

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17
Q

What are the histological forms of ameloblastoma

A

** follicular
* plexiform
* desmoplastic
First 2 most common

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18
Q

What is the growth pace of adenomatoid odonotgenic tumour

A

slow

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19
Q

What is the classic presentation of adenomatoid odontogenic tumour

A

Classic presentation is unilocular radiolucency with internal calcifications around crown of unerupted maxillary canine

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20
Q

How common is adenomatoid odontogenic tumour

A

3% of odontogenic tumours

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21
Q

What is the most common age for adenomatoid odontogenic tumour

A

10-20 year olds

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22
Q

Where is the most common location for adenomatoid odontogenic tumour

A

Anterior maxilla

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23
Q

What is the most common gender for adenomatoid odontogenic tumour

A

females

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24
Q

What is the growth pace for calcifiying epithelial odontogenic tumour (CEOT) aka pindborg

A

slow

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25
Q

What are calcifying epithelial odontogenic tumours associated with

A

50% associated with unerupted tooth

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26
Q

How common are calcifying epithelial odontogenic tumours

A

1% of odontogenic tumours

27
Q

What age group experience calcifying epithelial odontogenic tumours

A

40-50s

28
Q

Where is the most common location for calcifying epithelial odontogenic tumours

A

posterior mandible

29
Q

Which gender are calcifying epithelial odontogenic tumours most common with

A

males

30
Q

How do the margins of ameloblastoma appear on an xray

A

Well defined

Corticated

Potentially scalloped

31
Q

How do multicystic ameloblastoma appear on an xray

A

Most common is multicystic type which may have thick curved septae producing a ‘soap bubble appearance’

32
Q

How does a unicystic ameloblastoma radiographically appear

A

Less common is unicystic time, it would not have scalloped margins as it is one lesion

33
Q

Are ameloblastomas radiopaque or radiolucent on an xray

A

Primarily radiolucent with exception of the desmoplastic type

Depending on how many septae there are, it can be more radiopaque

34
Q

What is the impact of ameloblastoma on adjacent structures

A

Displacement of adjacent structures: commonly teeth and the inferior alveolar canal

Thinning of bony cortices – this is a sign of an aggressive lesion

‘Knife edge’ external root resorption – clean cut appearance. Characteristic sign

35
Q

How does ameloblastoma tend to grow

A

Typically expands in all directions equally

36
Q

How do the margins of adenomatoid odontogenic tumour appear on an xray

A

Well defined

Corticated/sclerotic

37
Q

Are adenomatoid odontogenic tumours usually unilocular or multilocular

A

unilocular

38
Q

Are adenomatoid odontogenic tumours radiopaque or radiolucent

A

Radiolucent

Majority have internal calcifications/radiopacities and increase as the tumour matures

These internal calcifications and radiopacities can vary in size and they can clump together

39
Q

What is the impact of adenomatoid odontogenic tumours on adjacent structures

A

May displace adjacent structures but external roto resorption is rare

40
Q

What are the associations of adenomatoid odontogenic tumours

A

75% associated with an unerupted tooth. Looks similar to a dentigerous cyst but typically it is attached to the CEJ.
It impedes eruption

41
Q

How do the margins of calcifying epithelial odontogenic tumours appear

A

Can be well/poorly defined

42
Q

Are calcifying epithelial odontogenic tumours uni or multilocular

A

Can be multi or unilocular

43
Q

Are calcifying epithelail odontogenic tumours radiolucent or radiopaque

A

Radiolucency often with internal radiopacities (variable)

Can have no, fine or coarse internal septa

44
Q

What are calcifying epithelial odontogenic tumours associated with

A

50% associated with unerupted tooth

45
Q

What are the histological features of a plexiform ameloblastoma

A

o Ameloblast-like cells arranged in stands and inbetween them you may get stellate reticulum lie tissue present
o Stellate reticulum is a group of cells located in the centre of the enamel organ of a developing tooth
o Supporting all of this there is fibrous tissue
o There is no connective tissue capsule
o The cells can grow and infiltrate into jaw bones which is the main reason for the high recurrence

46
Q

What are the histological features of a follicular ameloblastoma

A

o Islands present with fibrous tissue background
o Islands are bordered by cells that resemble ameloblasts (columnar cells with a darkly staining nucleus)
o The tissue in the middle is a loose tissue that resembles stellate reticulum of the tooth germ
o Other changes can take place within the ‘stellate’ reticulum like tissue e.g formation of squamous epithelium

47
Q

What is the management of ameloblastoma

A
  • Surgical resection with margin
  • 1cm around pathology is removed due to recurrence being common
  • <1% will transform to malignant ameloblastic carcinoma
48
Q

What are the histological features of AOT

A
  • Sometimes epithelial cells are arranged in a duct like structure or are present in sheaths or presents with a ‘rosette’ appearance (bottom right in the right picture)
  • Sometimes a degree of calcification is present which is reflected as specks of radiopacity in the x-ray
  • Well developed fibrous tissue capsule surrounding the cells so therefore removal of the tumour is straight forward as there is low recurrence
49
Q

How can you differentiate the dental follicle from the AOT

A
  • Dental follicle tends to be symmetrical all the way around the crown whereas this is not symmetrical, it bulges out more in the mesial of the canine
50
Q

How does the margins of an odontogenic myxoma appear on an xray

A

o Well defined radiolucency with/without a thin corticated margin

51
Q

Are odontogenic myxomas unilocular or multilocular

A

o When the lesion is small, it is often unilocular
o However as they get larger, they often become multilocular and have a scalloped margin
o The septae are curled and thin resembling a bubbly appearance/tennis racket appearance

52
Q

What is the growth pattern of odontogenic myxomas

A

o Grows along the bone before it expands buccal lingually

53
Q

Do odontogenic myxomas displace

A

o Initially they will scallop up between the roots rather than displace them, the teeth will eventually be displaced however

54
Q

Describe the histological features of odontogenic myxomas

A
  • Made up of myxoid tissue which is a loose type of connective tissue
  • Has a gelatinous consistency
  • Contains stellate like cells but they are fewer in number
  • Sometimes there may be small groups of odontogenic epithelium with myxoid tissue but these cells are inactive
  • Mesenchymal in origin
  • No fibrous tissue capsule so can infiltrate into adjacent bone and increase risk of recurrence post-removal
55
Q

What is the management of odontogenic myxomas

A
  • Curettage or resection depending on the size
  • High recurrence rate (1 in 4)
  • Follow up is important
  • The rate of recurrence is lower if the lesion is unilocular
56
Q

What is an odontoma technically

A
  • It is classed as a tumour by WHO, however technically it is a hamartoma which is defined as a mass of disorganized tissue native to a particular anatomical location
57
Q

How does odontoma appear similarly to teeth

A

o Mature to a certain stage (do not grow indefinitely)
o Can be associated with other odontogenic lesions e.g dentigerous cysts
o Surrounded by a dental follicle
o Lie above the IAC

58
Q

What decade is odontoma most common in

A

2nd

59
Q

What gender is odontomas more common in

A

females

60
Q

What are the two types of odontoma

A

compound
complex

61
Q

What is a complex odontoma

A

 Disorganised mass of dental tissue
 More common in the posterior body of the mandible

62
Q

What is a compound ondontoma

A

 Ordered dental structure
 May appear as mini teeth called denticles
 More common in the anterior maxilla
 More common by 2:1

63
Q

What are the histological features of odontoma

A

Enamel space is present as enamel is an inorganic structure so during slide preparation, when tissue is placed in a variety of different concentrations, it will dissolve the hard tissue so if enamel is fully calcified, then there won’t be any enamel in the odontoma