Functional groups and chirality and Drugs

Question 1

What functional group is this

Answer 1

Aryl

Question 2

What functional group is this

Answer 2

Hydroxyl

Question 3

What functional group is this

Answer 3

Alkoxy (ether)

Question 4

What functional group is this

Answer 4

Amino (amine)

Question 5

What functional group is this

Answer 5

Carboxyl (carboxylic acid)

Question 6

What functional group is this

Answer 6

Ester

Question 7

What functional group is this

Answer 7

Amido (amide)

Question 8

What functional group is this

Answer 8

Alkene

Question 9

What are prodrugs

Answer 9

inactive compounds that are converted into active drugs in the body

Question 10

What is chirality

Answer 10

A molecule with a chiral center which exists as a pair of non-superimposable mirror image (enantiomers)

Question 11

What must a chiral center have

Answer 11

4 side chains which are all different

Question 12

What does a full wedge indicate

Answer 12

the bond is coming out of the page

Question 13

What does a broken wedge indicate

Answer 13

the bond is going into the page

Question 14

How do you determine direction of priority for a chiral center

Answer 14

1. Locate stereocentre (C*)
2. Identify side chains (substituents) and assign priorities from 1(highest) to 4 (commonly H) based on atomic numbers
3. Move molecule so side chain 4 is pointing away (broken wedge)
4. read groups projecting out of the page in order from 1-3
5. Assign direction of priorities (clockwise vs counter clockwise) (R or S)

Question 15

What direction is R configuration (rectus)

Answer 15

Clockwise

Question 16

What direction is S configuration (sinister)

Answer 16

Counter clockwise