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Blood Bank Spring > RH Systems (D antigen) > Flashcards

RH Systems (D antigen) Flashcards

1
Q

Anti- A Anti-B Anti-A,B AI Cell B cell
0. 0 0 +4 +4

A

Type O

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2
Q

Anti- A Anti-B Anti-A,B AI Cell B cell
0 0 0 +4 +4
Anti-D +4

A

Type O pos

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3
Q

What is the Rh group named after?

A

Rheses Monkey

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4
Q

T/F Forwards type is serology

A

true

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5
Q

T/F you can not call blood types until you get a negative rxn

A

True,
Use a saline control

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6
Q

Anti- A Anti-B Anti-A,B AI Cell B cell
+4 +1 +4 0 0

Saline +1

What is wrong here?
What should you do?

A

Low rxn can be quality of blood for the low +1 (Anti-B)

Wash the fowards rxn
Throw in the fridge for 5-10min

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7
Q

Genetics of A type
What ag
what type of substance

A

H antigen
Type 2 substance

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8
Q

HXT of Rh types
1939
what happened with the woman
rxn?
immunization by?

A

1939 - Levine vs Stetson
woman gives birth to stillborn
rxn caused w compatible blood
woman immuized by fetus

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9
Q

Hxt of Rh types
1937

1940

A

1937 - Rheses monkey RBC

1940 - Rh factor landsteiner/weiner

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10
Q

Describe the LW system

Chromosome
High incidence
Low Incidence

A

more abundant on Rh pos than Rh negative cells
Chromosome 19 Lwa (High Incidence)
Lwb (low incidence) more common in finns

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11
Q

Describe the Rh System briefly
what ag
immunogenicity
inheritence?
disease states?
alleles?

A

Anti-D human
Highly immunogenic (most)
autosomal dominant inheritance
HDFN/TRXN
NO ALLELES

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12
Q

Describe the LW system briefly

A

Anti-LW monkey

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13
Q

What is the most polymorphic system of human Ag?
what to humans
Ag significance?
transfusion rxns?

A

Rh system
Intrinsic to humans
2nd most clinically significant Ag
transfusions are hemolytic

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14
Q

How do you form Anti-D?

A

immunizing event, doesn’t just naturally form

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15
Q

Describe Rhogam
timeframe

what type of shot?

looks like?
prevents?

A

1960s lots of babies died from HDFN
Low dose Anti-D shot

looks like anti-D in pt plasma
prevents real (allo) anti-D from forming

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16
Q

an intrinsic protein to the rbc membrane

A

Rh Ag, ONLY ON RBCS

17
Q

T/F Rh Ag begins developing on RBC as early as 16wks from conception

A

true

18
Q

Rh null has what rbcs?

A

stomatocytes
all neg

19
Q

Describe “Weak D” Du

A

Ag expression is so low it requires enhancement AHG for detect

AG INSIDE CELL

20
Q

Describe Partial D

A

Ag expression is variable depending on reagent

OUTSIDE OF CELL

21
Q

D-Ag expression

Rh+
Rh-

A

Rh pos - D is expressed
Rh Neg - D ag not expressed

22
Q

Diff gene based on ancestry
European
African
Asian

A

European - Deletion of RH
African - Mutation
Asian - adsoprtion/elution Del (weak)

23
Q

Do Weak D Du make Anti-D?

A

No, they do not make Anti-D, rxn is <2+ w/ pt cells

24
Q

Who can make Anti-D?

A

D neg
D partical

all or part of Ag is missing, pt sees norm Ag as foreign

(Del cannot
Du cannot)

25
Q

If the D tube is negative and the Automated tube is positive, what do you give the patient?

A

Give them negative

26
Q

Capital R means?

A

D ag is expressed

27
Q

Immune Stimulated

A

from transfusions or pregancy

28
Q

What does clinically significant mean

A

associated with HTR/HDFN

29
Q

what does immunogenic mean

A

Exposure to Ag positive cells results in Ab development
80% of healthy individuals

30
Q

Describe dosage effect

A

weaker reactivity on cells that only 1 dose of Ag (heterozygous expression) have

31
Q

Describe Anti-D overview
Ig
stimulation
detected
location

A

IgG
Immune stim
frequency detection by IAT
ONLY ON RBCS

32
Q

Do Rh negative babies make anti-D?

A

NO

33
Q

Describe RHAG

A

Rh associated glycoprotein
on chromosome 6

34
Q

RhO gene is on?

A

Chrom 1
no alleles or D (anthetical)

Blood Bank Spring (18 decks)

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