Chemo monoclonals

Question 1

Rituximab

Answer 1

-lymphoma (Hodgkins too)

Question 2

Trastuzumab (Herceptin)

Answer 2

inhibitor oncogenic receptor HER2 human epidermal growth factor receptor 2)

-Breast cancer
——
-cardiotoxicity (reversible)

Question 3

Bevacizumab

Answer 3

/
neutralizes VEGF (over expressed in cancer) preventing BV formation
——
-colorectal cancer

Question 4

Catumaxomab

Answer 4

binds EpCAM (overexpressed by cancer) and flags cell for immune system

Question 5

monoclonal side effects

Answer 5

hypotension
chills and fever
hypersensitivity

Question 6

Imatinib (Gleevec)

Answer 6

Kinase inhibitor
inhibits mutant BCR-ABL gene and PDGFR (platelet growth factor) not good

Question 7

Erlotinib

Answer 7

kinase inhibitor
inhibits EGFR (epidermal growth factor receptor)
——
-lung cancer
-pancreatic cancer

Question 8

Sorafenib

Answer 8

kinase inhibitor
targets many VEGFR, PDGFR, Raf family

Question 9

EGFR inhibitors

Answer 9

Erlotinib (lung)
Gefitinib (lung)
Afatinib (lung)
Osimertinib (lung)
Cetuximab (Colon)
Panitumumab (Colon

Question 10

kinase inhibitor side effects

Answer 10

GI upset
Fatigue
Headaches
cardio toxicity

Question 11

monoclonal vs small molecule

Answer 11

monoclonal and kinase inhibitors are more selective for cancer