Influenza drugs

Question 1

Amantadine

Answer 1

inhibit proton channel function in type A preventing decapsidation of gene material

Question 2

Rimantadine

Answer 2

inhibit proton channel function in type A preventing decapsidation of gene material
-closes open, seals closed
——–
-type A influenza
——–
-resistance from M2 proton channel mutation

Question 3

Oseltamivir

Answer 3

/
specific viral neuraminidase inhibitor
——-
-resistant type A and B
——–

Question 4

Zanamivir

Answer 4

/
specific viral neuraminidase inhibitor analog for sialic acid
——-
-resistant type A and B
——–

Question 5

Peramivir

Answer 5

/
neuraminidase inhibitor
——–
-influenza

Question 6

Xofluza

Answer 6

Prodrug of baloxavir
inhibits mRNA replication by inhibiting endonuclease of viral POL
——–
-reduces duration by 1.5days

Question 7

Remdesivir

Answer 7

/
inhibits RNA dep RNA pol to cause chain termination
——-
-ebola, RSV, influenza

Question 8

molnupiravir

Answer 8

Integrated into DNA as G then mutates to A causing mutation and deactivation of influenza

Question 9

Nirmatrelvir

Answer 9

part of paxlovid
peptidomimetic protease inhibitor

Question 10

Ritonavir

Answer 10

part of paxlovid
protease inhibitor and CTP3A4 inhibitor to increase activity