Renal Flashcards
What is the cause of orthostatic purpura?
Mixed cryoglobulinaemia
A patient with orthostatic pupura, haematuria and proteinuria presents? What renal condition is associated with this condition?
Membranoproliferative glomerulonephritis
Which glomerulonephritidies are linked with Hep C?
FSGS
Membranoproliferative glomeruloscletosis
Membranous
What are the histological findings of membranous glomerulonephritis?
Granular Ig G
Complement deposition
Immune complexes on outer aspect of basement membrane - appearing of spikes on silver stain
What underlying conditions are linked with membranous glomerulonephritis?
(Malignancy, CTD, infective, Drugs, other
Malignancy: bronchial carcinoma
Other malignancy: CLL, stomach, colon, lymphoma, melanoma
CTD: SLE, RA, Sjogrens, mixed CTD
Infections: Hep B, C, malaria, syphilis
Drugs: gold, penicilliamine, captipril, NSAIDs
Other: Sarcoidosis, GBS, PBC
What condition combines asthma, mononeuritis multiplex and purpuric rash?
What antibody is positive?
What intervention?
Eosinophilic granulomatous polyangitis
P-ANCA
high dose corticosteroids
4 glomerulonephritidies that cause nephrotic syndrome
Minimal change
Membranous
FSGS
Mesangiocapillary
2 glomerulonephritidies that present with nephritic syndrome
Diffuse proliferative
Rapid progressive GN
Minimal change
4 associations (2 drug, 2 cancer)
Appearance
Treatment
NSAIDs, gold
Hodgekins, thymoma
Normal histology
Electron microscopy: fusion of epithelial foot processes
Steroids, cyclophosphamide
Membranous Glomerulonephritis
Presentation
Antibodies
Appearance
Treatment
Proteinuria, nephrotic, can get haematuria
Anti-phospholipids A2
Granular IgG, complement deposition, immune complex spikes in subepithelium
ACEi/ARB; steroid and cyclophosphamide
FSGS
Presentation
Causes
Treatment (primary and secondary type)
Primary: IgM deposition
Secondary: HIV, obesity, nephrectomy
Nephrotic, protein, no haematuria
Primary: steroids and cyclophosphamide
Secondary: ACEi/ARB
Mesangioproliferative GN
Presentation
Causes
Appearance
Rx
Haematuria, proteinuria
IgA nephropathy, SLE, Alports
Increased mesangial cells, expansion of extra cellular matrix, IgA staining if IgA Nephropathy
ACEi/ARB
Mesangiocapillary GN
PRESENTATION
Rx
Nephrotic, proteinuria, non-visible
Haematuria
Steroids
DPGN
Presentation
Antibodies
Appearance
Rx
Sore throat then Nephritic
Low C3
Diffuse glomerulo proliferation
Self limiting
RPGN
Causes
Appearance
Treatment
Goodpastures
ANCA -positive vasculitis
Lupus nephritis
IgG in basement membrane, proliferation of epithelium
Steroids, cyclophosphamide, plasma exchange. Then steroid and azithromycin for maintenance
