Anemia (Normocytic)

Question 1

Reduction or cessation of blood cell production affecting one or more cell lines

Answer 1

BONE MARROW FAILURE

Question 2

Rare but potentially fatal bone marrow failure

Answer 2

Aplastic Anemia

Question 3

Aplastic Anemia symptoms:
P____
Reticulocyto____
____ Bone Marrow

Answer 3

Pancytopenia
Reticulocytopenia
Hypocellular

Question 4

Hypocellular Bone Marrow
Low CD____ cells under flow cytometry

Answer 4

CD34

Question 5

Acquired Aplastic Anemia type:
(70% of cases)

Answer 5

Idiopathic

Question 6

Acquired Aplastic Anemia type:
(10-15% of cases)

Answer 6

Secondary

Question 7

Acquired Aplastic Anemia Secondary:
Associated with exposure to certain drugs (most commonly _____), chemicals (commonly prolonged exposure to ____), ______, _____

Answer 7

chloramphenicol
benzene
radiation
infections

Question 8

T or F
Idiopathic Acquired Aplastic Anemia
Able to suppress the bone marrow in a predictable, dose-dependent manner

Answer 8

F
Secondary Acquired Aplastic Anemia

Question 9

Types of Aplastic Anemia:
(15-20% of cases)

Answer 9

Inherited Aplastic Anemia

Question 10

A chromosome instability disorder characterized by aplastic anemia, physical abnormalities, and cancer susceptibility

Answer 10

Fanconi Anemia

Question 11

Characterized by mucocutaneous abnormalities, Bone Marrow failure, and pancytopenia

Answer 11

Dyskeratosis congenita

Question 12

Triad of Dyskeratosis congenita:

Answer 12

Abnormal skin pigmentation
Dystrophic nails
Oral leukoplakia

Question 13

Multisystem disorder characterized by pancreatic insufficiency, cytopenia, skeletal abnormalities, and a predisposition for hematologic malignancies

Answer 13

Shwachman Bodian-Diamond Syndrome

Question 14

Rare disorder of erythropoiesis by a severe decrease in erythroid precursors in bone marrow

Answer 14

Pure Red Cell Aplasia

Question 15

Pure Red Cell Aplasia:
3 Lab Findings:
______ in the Bone marrow
Reticulo____
_____ WBC and Platelet count

Answer 15

Erythroid hypoplasia
Reticulocytopenia
Normal

Question 16

Types of PRCA:
- Idiopathic or immune
- Secondary—assoc. with malignancy or exposure to chemicals
- Transient erythroblastopenia of childhood (TEC)

Answer 16

Acquired PRCA

Question 17

Types of PRCA:
- Autosomal dominant inheritance
- Erythroid hypoplasia of early infancy
- Physical anomalies, craniofacial dysmorphisms, short stature, and neck and thumb malformations.
- Congenital Form

Answer 17

Diamond Blackfan Anemia (DBA)

Question 18

Family of inherited refractory anemias characterized by ineffective erythropoiesis and marrow erythroid multinuclearity

Answer 18

Congenital Dyserythropoietic Anemia

Question 19

Congenital Dyserythropoietic Anemia:
3 Lab findings:
_____ Bone Marrow
_____ in Bone Marrow erythroblasts
_____ WBC and Platelet Count

Answer 19

• Hypercellular
• Dysplastic changes
• Normal

Question 20

Congenital Dyserythropoietic Anemia types:
Presence of spongy chromatin of erythroblasts. “Swiss-cheese”
appearance

Answer 20

CDA I

Question 21

Congenital Dyserythropoietic Anemia types:
- most common subtype known as HEMPAS
- Hereditary Erythroblastic Multinuclearity with Positive Acidified Serum

Answer 21

CDA II

Question 22

CDA II:
Ham’s Acidified Serum test:
Sucrose Hemolysis test:

Answer 22

Positive
Negative

Question 23

Congenital Dyserythropoietic Anemia types:
Least common subtype

Answer 23

CDA III

Question 24

• Infiltration of tumor cells in the BM coming from tumors of lungs, breast, or prostate
• Cytokines and growth factors from tumor cells cause reduction of stem cells

Answer 24

Myelophthisic anemia

Question 25

Myelophthisic anemia:
Blood smear:

Answer 25

• Dacryocytes
• Nucleated RBCs and immature myeloid cells /Leukoeryhroblastosis
• Megakaryocyte fragments

Question 26

Myelophthisic anemia:
____ will show infiltrating tumor cells

Answer 26

Bone Marrow biopsy

Question 27

Anemia of Chronic Kidney Disease/Renal Failure
Root cause:

Answer 27

Inadequate EPO production

Question 28

T or F
Anemia of Chronic Kidney Disease/Renal Failure:
Uremia causes increased RBC fragility

Answer 28

T

Question 29

Anemia of Chronic Kidney Disease/Renal Failure:
Lab findings:
Reticulocyto____
Presence of _____

Answer 29

• Reticulocytopenia
• Echinocytes/Burr cells