FIP

Question 1

What are the two pathotypes of feline coronavirus?

Answer 1

(Feline enteric coronavirus and feline infectious peritonitis virus)

Question 2

(T/F) Feline infectious peritonitis virus is not shed or shed at very low levels in the feces of infected cats.

Answer 2

(T, this is why it is considered noncontagious)

Question 3

What two cell types does feline infectious peritonitis virus infect (and cause subsequent viremia)?

Answer 3

(Monocytes and macrophages)

Question 4

The humoral response/cellular immunity (choose) is exaggerated in feline infectious peritonitis virus infections.

Answer 4

(Humoral response is exaggerated → hyperactivation of macrophages, intense neutrophil recruitment, overproduction of proinflammatory cytokines)

Question 5

What results from the suppressed cellular immunity associated with FIP infections that can be indicated by routine blood work?

Answer 5

(Lymphopenia, also suppresses NK cells and there is a lack of certain T cell activation and regulation factors (IL-10, IL-12))

Question 6

FIP effusions are high/low (choose) in protein and high/low (choose) in cellularity.

Answer 6

(High protein, low cellularity)

Question 7

Which form of FIP is more severe and more common?

Answer 7

(Wet form)

Question 8

What blood work changes are more common in the effusive form of FIP?

Answer 8

(Hyperbilirubinemia and lymphopenia; dry can have lymphopenia but it is less common)

Question 9

What organs are most commonly affected with granulomatous parenchymal lesions in the dry form of FIP?

Answer 9

(Eye and CNS, others are ileocolic junction, ileocecocolic ln, mesenteric lnn, and kidneys)

Question 10

Do cats with wet or dry (choose) FIP have some, although weak, active cellular immunity?

Answer 10

(Dry)

Question 11

Which two breeds of cat are overrepresented associated with the dry form of FIP?

Answer 11

(Burmese and Birmans)

Question 12

What is the gold standard for diagnosis of FIP?

Answer 12

(Biopsies with histopath and IHC; cannot commonly be performed premortem)

Question 13

Describe the CBC of a cat with FIP.

Answer 13

(Regenerative or non-regenerative microcytic anemia, band neutrophilia, lymphopenia (esp with wet form), and thrombocytopenia)

Question 14

(T/F) If you are presented with a cat that you suspect has FIP based on there being abdominal effusion but they do not have lymphopenia, you can move FIP very low on your ddx list.

Answer 14

(T)

Question 15

What is the most common serum chem change noted with FIP infections?

Answer 15

(Hyperglobulinemia)

Question 16

Describe the fluid analysis results of a FIP effusion.

Answer 16

(High protein count with a low A:G ratio, moderately low cell count, neutrophils and macrophages are the predominant cell types)

Question 17

What is the purpose of the rivalta test?

Answer 17

(To rule out FIP)

Question 18

Why are antibody tests not good for diagnosing and even ruling out FIP?

Answer 18

(FIP antibody tests test for FCoV which lots of cats have without signs of FIP, so a positive anti-FCoV Ab does not equal FIP, also not good for ruling out because a negative anti-FCoV Ab does not mean the cat cannot have FIP)

Question 19

Is an RT-PCR (performed on effusion, FNAs, CSF, and/or aqueous humor) meant to rule in or out (choose) FIP?

Answer 19

(Rule in, it has excellent specificity so you can trust a positive, only good sensitivity so a negative doesn’t necessarily guarantee the animal does not have FIP)

Question 20

Has immunosuppression (corticosteroids, cytokine inhibitors, interferon, etc.) or immunostimulation for treatment of FIP found to be effective?

Answer 20

(No, neither has found to be effective besides anecdotal cases)

Question 21

What does the nucleoside analogue GS-441524 do to treat FIP?

Answer 21

(Strongly inhibits FIP viral replication)

Question 22

(T/F) As of today there are no commercially available, effective therapies for FIP.

Answer 22

(T, nucleoside analogues are not approved by the FDA and your recommending/prescribing of them is illegal (so do it under the table for a little thrill))