Polymyositis

Question 1

what 3 organs are most commonly affected in autoimmune myopathies?

Answer 1

muscle
skin
lungs

Question 2

inflammatory disease of the striated muscle in which the muscle fibers are attacked, leading to muscle weakness, swelling, tenderness, and tissue damage.

Answer 2

polymyositis

Question 3

inflammatory disease of the striated muscle in which the muscle fibers are attacked, leading to muscle weakness, swelling, tenderness, and tissue damage; includes a skin rash

Answer 3

dermatomyositis

Question 4

which myopathy has a more severe/malignant risk?

Answer 4

dermatomyositis

Question 5

what is the most common clinical feature of polymyositis?

Answer 5

symmetrical proximal muscle weakness

Question 6

what are 2 body rashes present in dermatomyositis?

Answer 6

V sign
Shawl sign

Question 7

rash on the face, neck, and anterior chest

Answer 7

V sign

Question 8

rash on the shoulders and upper back

Answer 8

shawl sign

Question 9

dermatomyositis rash around the eyes, bridge of nose, and cheeks

Answer 9

heliotrope rash

Question 10

dermatomyositis papules that are erythematous and scaly lesions over the knuckles. what is it associated with?

Answer 10

gottron’s papules

dermatomyositis

Question 11

3 associated findings in polymyositis and dermatomyositis?

Answer 11

arthralgias
CHF
interstitial lung disease

Question 12

perifasicular atrophy is pathognomonic for?

Answer 12

dermatomyositis

Question 13

what lab is significantly elevated to correspond to the degree of muscle necrosis?

Answer 13

CK

Question 14

what lab is elevated to suggest perimysial involvement and helpful in cases when CK is normal?

Answer 14

aldolase

Question 15

what is the myositis-specific autoantibody?

Answer 15

Anti Jo-1

Question 16

what will be abnormal in 90% of patients with myositis?

Answer 16

electromyography (EMG)

Question 17

what diagnostic will confirm muscle inflammation and muscle fiber fibrosis?

Answer 17

muscle biopsy

Question 18

what will a muscle biopsy show?

Answer 18

lymphocytic infiltrates

Question 19

what diagnostic can detect early and patchy muscle involvement, revealing evidence of edema and/or fasciitis?

Answer 19

MRI

Question 20

what is the 1st line treatment for myositis?

Answer 20

high dose prednisone for several months

Question 21

what is the 2nd line treatment for myositis? (2)

Answer 21

methotrexate
azathioprine

Question 22

what is the 3rd line treatment for myositis?

Answer 22

IVIG

Question 23

what is the largest problem in treating myositis?

Answer 23

obtaining an accurate diagnosis