158b PTH histo/path Flashcards Preview

Endocrine - DVR > 158b PTH histo/path > Flashcards

Flashcards in 158b PTH histo/path Deck (18):
1

PT embryogensis?

upper pair - 4th branchial cleft
lower pair - 3rd branchial cleft

2

PT migtation can cause what?

aberrant locations

mediastinum, carotid sheath, behind esophagus

3

where are the PT located? blood supply? nerves nearby?

posterior of thyroid

inferior thyroid artery from subclavian
superior thyroid artery from external carotid

recurrent laryngeal nerve to vocal cord?

4

PT principle cell?

chief cell with PTH

round nuclei at center of cell

5

oxyphil cell

in PT

larger than chief cells

granular eospinophilic cytoplasm from increaesd mitochondria --> pink and clustered

no secretory granulees --> adenoma isn't functioning

6

what causes primary hyperPT?

adenoma - most common
hyperplasia
carcinoma - least common

7

what does hyper PT cause?

hypercalcemia

8

secondary hyperPT causes?

intestinal disease/renal disease --> hypocalcemia --> excess PTH

reversible with normal kidney function

9

tertiary hyperPT?

autononmous PT after treatment --> hypercalcemia

10

what inherited tumor sydnromes can cause hypterPT?

MEN-1
MEN-2A

most cases are sporadic though

11

clinical features of hyper PT?

Stones (renal), bones, moans (GI tract), psychic groans

hypercalcemia --> nephrolethiasis
GI --> ulcers, pancreattitis, gall stones
psychic --> leathargy, seizures, depressions
bone --> osteoporosis, brown tumor

12

bone manifestiations of P-hpt?

loss of bone --> osteoporesis
osteitis fibrosa cystica --> holes in bone
subperiosteal resorption
brown tumor

13

where do pt adenoma present other than the pt gland?

thymus in antirior mediastunium

14

PT Adenoma

unilaterla

solid - uniform without fat

variety of appearances --> can appear like a thyroid follicular adenoma/carcinoma

15

PT carcinoma

rare,

invasion

cytologic atypia is NOT diagnostic

bone disease

16

what causes bone pathology in P-HPT?

activated osteoclasts --> dissecting osteitis

osteoporosis

osteitis fibrosa cystica

brown tumors

17

treatment of HPT?

surgery - everything reverses to normal

18

cause of hypoPT?

surgery
other uncommon causes are autoimmune, infectious disease