Flashcards in 166b fat pathophysiology Deck (12):
men vs women
women have more fat at the same BMI
men have more muscle
adipokines - lipotoxicity
TNG-a, leptin, cytokines all go up (except adiponectin -- protective)
effect other organs
what is the worst kind of fat?
abdominal fat - visceral fat
causes dyslipidemia, dysfunction, and insuling resistance
what is the only thing that fat secretes which is protective and secreted more with less fat?
what happens with fat gain in regards to cell types?
more fat --> macrophages and inflammation
does lipsection improve health outcomes?
how does visceral fat affect insulin resilance?
visceral fat/liver fat increases insulin resistance --> atherosclerosis
BMI isn't a component but high waist circumference is the biggest risk factor
which fat people get CV disease?
those with metabolic syndrome otherwise still insulin sensitive
obesity and GERD, diaphragmatic movement
increased due to high abdomninal P
reduced ERV, FRC, RV - can't take a deep breath
much smaller reserve
respiratory consequences of obesity
requires higher RR b/c higher BMR --> blow off more CO2 (high PaO2, low PaCO2) --> cor pulmonale, OSA
compliance of chest wall goes down due to mass