166b fat pathophysiology Flashcards Preview

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Flashcards in 166b fat pathophysiology Deck (12):
1

men vs women

women have more fat at the same BMI
men have more muscle

2

adipokines - lipotoxicity

TNG-a, leptin, cytokines all go up (except adiponectin -- protective)

effect other organs

3

what is the worst kind of fat?

abdominal fat - visceral fat

causes dyslipidemia, dysfunction, and insuling resistance

4

what is the only thing that fat secretes which is protective and secreted more with less fat?

adiponectin

5

what happens with fat gain in regards to cell types?

more fat --> macrophages and inflammation

6

does lipsection improve health outcomes?

no

7

how does visceral fat affect insulin resilance?

visceral fat/liver fat increases insulin resistance --> atherosclerosis

8

metabolic syndrome

BMI isn't a component but high waist circumference is the biggest risk factor

9

which fat people get CV disease?

those with metabolic syndrome otherwise still insulin sensitive

10

obesity and GERD, diaphragmatic movement

increased due to high abdomninal P

reduced ERV, FRC, RV - can't take a deep breath
much smaller reserve

11

respiratory consequences of obesity

smaller reserves

requires higher RR b/c higher BMR --> blow off more CO2 (high PaO2, low PaCO2) --> cor pulmonale, OSA

compliance of chest wall goes down due to mass

12

CV and obesity

increased blood volume, increased CO, increased LVEDV --> LVH (usually eccentric) --> LAE --> AF

HF risk is proportional to BMI