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Pathology II > Pathology 2 Final > Flashcards

Pathology 2 Final Flashcards

1
Q

What disease is associated with a mutation in type 1 collagen?

A

Osteogenesis imperfecta

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2
Q

Give a potential diagnosis based on this xray and histological slide:

xray: multilocular radiolucency crossing midline of anterior mandible, root resorption (third molars not in yet so its a kid)

histology: multinucleated giant cells (Aka chocolate chip cookies)

A

Central giant cell granuloma

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3
Q

All of the following describe mccune Albright syndrome except:

a- cafe au lait pigmentation
b- multiple endocrine lesions
c- polyostotic disease of fibrous dysplasia
d- hypo function of cells involved in the tissues

A

d- hypo function of cells involved in the tissue

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4
Q

What is a potential diagnosis for a patient with intestinal polyps?

A

gardner syndrome

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5
Q

An immunohistochemistry test for multiple myeloma would likely present what?

A

monoclonal light chain

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6
Q

What disease is associated with amyloid deposits

A

multiple myeloma

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7
Q

What is the gene mutation for cherubim?

A

SH3P2

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8
Q

What would you expect to see under an electron microscope for langerhans cell histocytosis?

A

birbeck granules

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9
Q

What disease is commonly associated with supernumerary teeth?

A

Gardners syndrome

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10
Q

Differential diagnosis for xray:

  • posterior mandible
  • large well circumscribed radiolucency
  • involving the roots
  • tooth “Floating in air”
A

Langerhans cell histiocytosis

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11
Q

Patient is 70 years old and present with this radiograph (punched out radiolucencies all over skull). What is your diagnosis?

A

multiple myeloma

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12
Q

Upon a biopsy of a lesion, what are you expecting to find for the histology of a focal osteoporotic defect?

A

hematopoietic bone marrow defect

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13
Q

Patient presents with this lesion that hasn’t expanded in 10 years. Pulp testing reports VITAL. What is your diagnosis?

xray:
- associated with molar-premolars
- radiopacity

A

idiopathic ostosclerosis

  • increased radiopacity, non-expansile, mandibular molar-premolar area, vital teeth
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14
Q

List 3 differential diagnosis for this xray:

A
  1. OKC
  2. Conventional amelobastoma
  3. Central giant cell granuloma
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15
Q

Radiograph of a unilocular radiolucency, what can this NOT be?

A

botryoid odontogenic cyst (mulilocular)

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16
Q

radiograph of odontoma. what cyst is most commonly associated?

A

Calcifying odontogenic cyst (gorlin cyst)

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17
Q

Histology presents a corrugated surface, prominent, palisaded, hyperchomatic basal layer. What is most likely the radiographic presentation?

A

multilocular radiolucency (OKC)

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18
Q

What is the reason for the recurrence of OKC?

A

satelite cysts (daughter cysts)

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19
Q

A 50 year old male comes in with this radiograph (huge multilocular mass in posterior mandible)

What is NOT in your differential diagnosis?

A

Ameloblastic fibroma because this is a “kiddie” tumor

20
Q

Which of the following will you not see with nevoid basal cell carcinoma syndrome? (gorlin syndrome)

A

multiple ameloblastomas

you will see: bifid ribs, multiple OKCs, nervous system neoplasms (medulloblastoma)

21
Q

Histology shows ghost cells, what is this?

A

calcifying odontogenic cyst

22
Q

Patient presents with vital teeth and a radiolucency that scallops the border of the roots. On biopsy the surgeon reports and empty cavity. The patient reports having sports injury in the area.

A

traumatic bone cyst

23
Q

What presents with normal hematopoietic bone marrow histology?

A

osteoprotic bone defect

24
Q

Histology shows REVERSE POLARITY of basal cell nuclei, NUCLEAR HYPERCHROMATISM, NUCLEAR PALISADING, and SUBNUCLEAR VACUOLATION. What is it?

A

unicystic ameloblastoma

25
Q

Patient presents with a lesion characterized by whirling of the epithelium and pseudo ducts. What is is?

A

adenomatoid odontogenic tumor

WHIRLING OF EPITHELIUM
PSEUDODUCTS

26
Q

What can present as MULTIlocular radiolucency?

A

botryoid odontogenic cyst

27
Q

Which of the following is most aggressive?

a- ameloblastic fibroma
b-complex odontoma
c- odontogenic myxoma
d- compound odontoma

A

c- Odontogenic myxoma

28
Q

What is the least likely to be a MULTIlocular radiolucency?

A

periapical cyst

29
Q

Histology shows PINK POLYGONAL POLYHEDRAL epithelial cells with calcifications. What is this?

A

Calcifying epithelial odontogenic tumor

30
Q

Histology shows amyloid and Liesegang ring calficiations. What is it?

A

calcifying epithelial odontogenic tumor

31
Q

A biopsy was done on a radiopaque lesion. Histology shows that the lesion came out whole. What is it?

A

cementoblastoma

32
Q

Patient presents with a NON-vital tooth and radiopacity associated with the apex of the root. what is this?

A

condensing osteitis

33
Q

What presents with multifocal radipacities?

A

Gardner syndrome

34
Q

Picture of brown/blue teeth. Patient presents with multiple bone fractures and blue sclera. What is this?

A

osteogenesis imperfecta

35
Q

What has a cotton wool radiographic appearance?

A

Paget disease of bone

36
Q

What is a developmental form of a benign fibro-osseous lesion?

A
  1. Fibrous dysplasia
  2. osseous dysplasia
  3. ossifying fibroma
37
Q

Which form of fibrous dysplasia involves cafe au lait pigmentation, endocrinopathy, and cranofacial dysplasia?

A

mccune albright syndrome

  1. cafe au lait pigmentation
  2. fibrous dysplasia
  3. endocrinopathy
  4. craniofacial dysplasia
38
Q

Patient presents with a fibrous lesion. Histology reveals “Chinese-like characters”, what is it?

A

fibrous dysplasia

39
Q

Patient presents with radiopacicites associate with the apex of several anterior mandibular teeth. The finding is incidental. What is it?

A

periapical cemento-osseous dysplasia

40
Q

After extraction of a mandibular molar, a radiograph shows a radiopaque lesion at the extraction site. what is it?

A

focal cemento-osseous dysplasia

41
Q

Diffuse radiopacities throughout the maxilla & mandible. What is it?

A

florid cemento-osseous dysplasia

42
Q

A lesion is biopsied and came out in one piece. What is it?

A

cemento-ossifying fibroma

43
Q

Patient presents with histology of extravasated RBCs, hemosiderin, and multinucleated giant cells. Blood tests revealed an increase in parathyroid hormone. What is this?

A

Brown tumor (central giant cell granuloma, but hyperparatyrhoidism = brown tumor)

44
Q

What is the chronic focal form of langerhans cell histocytosis?

A

eosinophilic granuloma

45
Q

localized, symmetrical widening of the PDL space is the most ominous sign of:

A

osteosarcoma

46
Q
A

Pathology II (17 decks)

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