17 respiratory pharm Flashcards Preview

01 Renal Respiratory > 17 respiratory pharm > Flashcards

Flashcards in 17 respiratory pharm Deck (15):
0

Omalizumab

Anti IgE receptor antibody for severe refracory asthma or concomitant allergic rhinitis

SubQ every 2-4 wks

SE/ Inection site RXN or anaphylaxis

1

Bronchodilators

B2 andrenergic agonists
Theophilline (methylxanthine)
Anticholinergic(muscarinic receptor antagonistt)

2

Albutereal, Salmeterol and formoterol

B2 agonists MOA:
*decrease calcium and SM constriction
*prevent mast cell degranulation
*prevvent bronchial edema
*enhance mucocilliar escalator
Reduce reflex cholinergic constriction

Albuterol 3-6hr -acute asthma attacks
Salmeterol and fomotorl 12 hr- Asthma, bronchospasm, COPD (use with caution can cause problems n children

3

B2 agonist SE

Dose related and worse in patients with CV disease

tremor, tachycardia(direct and reflex), hypokalemia, restlessnes, VQ mismatch hypoxemia

4

Theophilline

Methylxanthine- PDE inhibitor (SM relaxant) and antagonizes adenosine receptors (blockse release of leuks and histamines)

Inexpensive treatment for severe asthma and COPD

Toxicity:
HA, dizziness, palpitation, nausea, hypotention, tachycardia, restlessness,agitation, seizures

5

Ipratropium bromide/ tiotropium

*Anticholinergics- blockade of M3-CA pathway ***COPD!!!***
***Treats severe acute asthma after B2 agonists fail***additive (or 2nd choice)
Ipratropium short acting- 30-90 min onset, 4-6 hour duration,
tiotropium longer onset 24hr duration

*Relaxes airways, Dcr. mucous secretion

SE: Dry as a bone, Blind as a bat, hot as a hare, sick as a dog, red as a beet, mad as a hatter

6

Beclomethasone

Inhaled Steroid.
FIRST LINE ASTHMA TREATMENT for persistant asthma requiring rescue inhalor >2 times per week(NOT RESCUE HOWEVER)

Twice daily

*antiinflammatory for treatment of chronic asthma inflammation
recruits histone deacetylase and blocks HAT

Deccreases cytokines, inflammatory cells, endoothelial leakage, mucous secretion, increases B receptors on SM muscle

7

combined inhalor

LABA and corticosteroid
enhance each others receptors
additive effect

8

Systemic steroid treatment

Predisolone and prednisone oral
for acute exacerbations of asthma (though not rescue)
Givven morning to decrease adrenalsuppression

IV Hydrocortisone for sevver decline inlung function <30% and non responsive to B2agonists

9

Inhaled steroid SE

Dermal thinning and skin capillary fragility, cateracts and osteoporosis - especially if oral as well, vocal atrophy (40%),

10

Zileutan

blocks formation of LTEs

11

Zafirlukast

LTE receptor antagonist

used for mild to moderate asthma (though less effective than ICS) Add on

SE: rare hepatic dysfunction

12

COPD treatment

1)smoking cessation and self management
2)bronchodilators (antimuscarinic)
3) inhaed corticosteroidds
4)pulmonary rehab
5)oxygen
6)surgery

13

Dornase Alpha

Inhaled DNASe -decreasessputum viscosity

14

IVacaftor

Very expensive treatment dor patients with G551Dmutation
helps open these channels