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Flashcards in 29 Respiratory viruses Deck (11):
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Influenza

16HA, 9NA
Distruction of respiratory epithelium by 3 days post infection
^ succeptability to 2ndary bacterial infections (Strep pneumoniae, staph aureus, haemophilus).
*Rare complications like myostis/cardiac- guianbarre, encephalitis, reyes

1

Flu treatment

Attenuated live intranasal virus
Trivalent formalin vaccines

Antivirals
-amantadine and ramantadine- blocks m2 uncoating (easy resistance)
-Zanamavir and oseltamivir (block neuuraminidase and prevent release

2

Rhinovirus (PICORNA)

Common cold -150 serotypes
Mild and self limiting
Temp sensitive 33-37
fomite and secretion transmission
VP1 receptor uncoats (new drugs might block this)

3

Enteroviruses(Picorna)

Naked + ssRNA
polio, coxsackie, echovvirus
respiratory infections
undifferentiated fevers

No treatments

4

Coronavirus

Common cold
Enveloped + RNA
Epithelial URIs
no vaccines
SARS and MERS (not highly contageous)

5

Parainfluenza virus

- ss RNA Naked
Late fall and winter
nosocomial
CROUP- in types 1 and 2
Type 3 - RSV like causing infant bronchiolitis

6

RSV

- SS enveloped RNA
Respiratory infection only- no viremia
*Syncitia formed by multinucleated giant cells- lots of inflammatory cytokines
Winter prevalence
NO IMMUNOLOGIC PROTECTION

Supportive care
Immunocompromised or premature infants:
-aerolosized Ribovirin, sometimes anti RSV fusion protein antibodies

7

Metapneumovirus

- SS enveloped

RSV like- but milder

8

Hendra and Nipahvirus

-SS enveloped
High mortality

9

Adenovirus

DS DNA Naked

Flu-like symptoms
pneumonia
Pharyngocunjunctival fever

WIDE SPECTRUM OFD DISEASE- can cause hemorrhagic cystitis
Vaccine for military only

10

Measels

paramyxovvirus

Maculopapular rash
cough Conjunctivits, cold, croup, pneumonia - largest cause of childhood death with pneumonia.