17 - Tubular Disorders Flashcards Preview

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Flashcards in 17 - Tubular Disorders Deck (10):
1

etiologies of tubule and interstitial kidney dz

infections
NSAIDs, other nephrotoxic drugs
sickle cell, myeloma, lymphoprolif
obstruction
heavy metals
PCKD, medullary cystic dz, medullary sponge kidney etc
DM, hyperuricemia, cystinosis, K depletion, oxaluria hypercalcemia
immunologic - SLE, transplanted kidney, cryoglobulinemia, sjogrens, goodpasture

2

drugs causing interstitial kidney inflammation

abx - PCNs, cephalosporins, fluoroquinolones, rifampin
sulfonamides
NSAIDs
phenytoin
thiazides, furosemide
cimetidine, allopurinol, cyclosporine, omeprazole

3

interstitial and tubular kidney dz often present w/

hematuria (can be micro), non-nephrotic proteinuria, flank pain

4

pattern of NSAID nephropathy

starts in medulla and works its way out until its got whole papilla

5

type of patient who gets NSAID nephropathy

female
middle age
personality disorder - anxious/neurotic
addictive behavior - smoking, alcohol, laxatives, sedatives
cause of analgesic use often headache

6

tx of NSAID nephropathy

discontinue analgesics
control BP (ACEIs)
tx urinary infxns
expand vasc volume
psych support
monitor for cancer

7

herbal that causes urothelial carcinoma

aristolochic acid

8

which genetic dz causes papillary necrosis

sickle cell

9

myeloma cast nephropathy

kappa and lambda chains directly toxic to PCT > cast formation
small anion gap

10

1 heavy metal that causes chronic tubulointerstitial nephropathy and 3 that cause acute

chronic - lead
acute - bismuth, mercury, uranium