Renal anatomy Flashcards
osmotic diuretic that increases tubular fluid osmolarity in the PCT –> increased urine flow
Mannitol
what in the basolateral membrane extrudes Na from renal tubular cells into the interstitium?
Na/K ATPase
a sodium-phosphate cotransporter which serves as the primary functional regulator of phosphate reabsorption.
NPT2
induces NPT2 endocytosis → ↓ reabsorption of phosphate and ↓ reabsorption of HCO3-
Parathyroid hormone
PTH induces endocytosis of what?
NPT2
Reabsorption of filtered HCO3- is directly coupled to renal H secretion via the action of carbonic anhydrase and XXXX.
Na/H+ antiporter
synthesized from glutamine within the cells lining the PCT
Ammonia (NH3)
Fraction of filtered Na+ and H2O reabsorption in PCT
~67%
diuretics that act in the PCT by inhibiting the reabsorption of filtered HCO3-.
Carbonic anhydrase inhibitors (eg, acetazolamide)
Where do carbonic anhydrase inhibitors (eg, acetazolamide) work?
PCT
Important transporter in the thick ascending limb of Henle’s loop
Na-K-2Cl cotransporter
3 loop diuretics
furosemide, bumetanide, ethacrynic acid
block the NKCC (Na/K/2Cl-) symporter in the TAL (thick ascending limb) of Henle’s loop
Loop diuretics
allow electrochemical potential gradient to drive further reabsorption of cations: K, Mg+ and Ca+
K leak channels in the luminal membrane
the renal artery emerges from the descending aorta at the level of
L2 (second lumbar vertebra).
