Flashcards in 19 - neuroinflammation Deck (16):
7 immune privileged sites
eye, brain, pregnant uterus, ovary, testis, adrenal cortex, hair follicles
most common + earliest feature of all neuroinflammatory disorders? effect?
microglia activation: can have neurotoxic or neuroprotective functions
neuron-glial interactions keep microglia in what state? then what changes it?
in a down regulated state. changes in microenvironment = changes in microglia that can be adapative or mal adaptive.
three states of microglia and result?
resting - homeostasis. primed = sickness behaviour. activated = neuronal dysfunction.
two types of microglia
M1 pro inflammatory. M2: anti inflammatory, protective
MS: induced by?
inflammation: immune mediated destruction within CNS
MS: first cause of?
non traumatic disability in young adults of north america + europe
MS: females vs. males
more common in females, 3:1
pathological features in MS
demyelination, decreased axonal density in plaques,
characteristics of NDDs? (4)
affect specific parts/functional systems of NS. begin insidiously, after long period of normal NS function and pursue a gradually progressive curve. minimal increase in proteins in CSF. no change/only volumetric reduction with imaging.
MS vs. normal NDD: imaging?
normally MRI can just see atrophy: but in MS can see changes in white matter, lesions
see oligoclonal bands in CSF. normally absent, but in MS will see the bands
genetics and MS risk?
some HLA loci contribution, MZ twins only show 18% recurrence risk
EAE in animals?
inject with myelin basic protein, will induce disease that is mediated by T cells. disease can be transmitted from transfer of T cells from affected individual
MRi spectroscopy: neuronal marker. NAA peak decreased