19 - neuroinflammation Flashcards Preview

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Flashcards in 19 - neuroinflammation Deck (16):
1

7 immune privileged sites

eye, brain, pregnant uterus, ovary, testis, adrenal cortex, hair follicles

2

most common + earliest feature of all neuroinflammatory disorders? effect?

microglia activation: can have neurotoxic or neuroprotective functions

3

neuron-glial interactions keep microglia in what state? then what changes it?

in a down regulated state. changes in microenvironment = changes in microglia that can be adapative or mal adaptive.

4

three states of microglia and result?

resting - homeostasis. primed = sickness behaviour. activated = neuronal dysfunction.

5

two types of microglia

M1 pro inflammatory. M2: anti inflammatory, protective

6

MS: induced by?

inflammation: immune mediated destruction within CNS

7

MS: first cause of?

non traumatic disability in young adults of north america + europe

8

MS: females vs. males

more common in females, 3:1

9

pathological features in MS

demyelination, decreased axonal density in plaques,

10

characteristics of NDDs? (4)

affect specific parts/functional systems of NS. begin insidiously, after long period of normal NS function and pursue a gradually progressive curve. minimal increase in proteins in CSF. no change/only volumetric reduction with imaging.

11

MS vs. normal NDD: imaging?

normally MRI can just see atrophy: but in MS can see changes in white matter, lesions

12

CSF: MS?

see oligoclonal bands in CSF. normally absent, but in MS will see the bands

13

genetics and MS risk?

some HLA loci contribution, MZ twins only show 18% recurrence risk

14

EAE in animals?

inject with myelin basic protein, will induce disease that is mediated by T cells. disease can be transmitted from transfer of T cells from affected individual

15

NAA ?

MRi spectroscopy: neuronal marker. NAA peak decreased

16

3 targets for MS treatment

inflammation, neurodegeneration/demylination, failure of repair and gliosis