24 - Infections Flashcards Preview

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Flashcards in 24 - Infections Deck (12):
1

astrocytes: what protein

glial fibrillary acidic protein GFAP

2

most abundant cell type in CNS?

astrocytes

3

types of astrocytes

Type I, Type II, fibrillary, protoplasmic, radial

4

astrocytes major functions (4)

biochemical support of endothelia cells that form BBB, provide nutrients to nervous tissue, maintain extracellular ion balance, role in repair/scarring process after injury

5

oligodendrocytes: what %? dervied from? what are they?

5 - 10 % of all CNS cells. neuroectoderm. myelin producing cells that provide structural support for axons satellite cells

6

major functions of astrocytes (2)

produce myelin = increase axonal transmission speed, reduce axonal capacitance during saltatory propagation

7

oligodendrocytes: prototype expressed proteins (3)

myelin basic protein MBP. proteolipid protein PLP. 2'3' cyclic nucleotide 3' phosphodiesterase CNPase

8

microglia: what %? derived from?

~10% of all CNS cells. from yolk sac, but also from infiltrating blood macrophages and monocytes.

9

major functions of microglia (2)

sentinel sensors of CNS, recognize + respond to potentially damaging stimuli (like injuries or infections)

10

what do microglia do (2)

phagocytose damaged cells, infectious agents, blood. produce inflammatory molecules.

11

3 prototype expressed proteins for microglia

MHC Class II, Iba-1, CD68

12

microglia: part of what immune system?

innate (first line non specific, rather than the adaptive)