Flashcards in 24 - Infections Deck (12):
astrocytes: what protein
glial fibrillary acidic protein GFAP
most abundant cell type in CNS?
types of astrocytes
Type I, Type II, fibrillary, protoplasmic, radial
astrocytes major functions (4)
biochemical support of endothelia cells that form BBB, provide nutrients to nervous tissue, maintain extracellular ion balance, role in repair/scarring process after injury
oligodendrocytes: what %? dervied from? what are they?
5 - 10 % of all CNS cells. neuroectoderm. myelin producing cells that provide structural support for axons satellite cells
major functions of astrocytes (2)
produce myelin = increase axonal transmission speed, reduce axonal capacitance during saltatory propagation
oligodendrocytes: prototype expressed proteins (3)
myelin basic protein MBP. proteolipid protein PLP. 2'3' cyclic nucleotide 3' phosphodiesterase CNPase
microglia: what %? derived from?
~10% of all CNS cells. from yolk sac, but also from infiltrating blood macrophages and monocytes.
major functions of microglia (2)
sentinel sensors of CNS, recognize + respond to potentially damaging stimuli (like injuries or infections)
what do microglia do (2)
phagocytose damaged cells, infectious agents, blood. produce inflammatory molecules.
3 prototype expressed proteins for microglia
MHC Class II, Iba-1, CD68