19.2 formation of blood cells Flashcards
process by which the formed elements of blood develop
hemopoiesis
primary site of hemopoiesis in last 3 months beforee birth and continues as the source of blood cells after birth and throughout life
red bone marrow
about 0.05-1% of red bone marrow cells are called
pluripotent stem cells (or hemocytoblasts)
where are pluripotent stem cells derived from
menenchyme
in order to form blood cells, pluripotent stem cells in red bone marrow produce 2 further types of stem cells which are
myeloid stem cells
lymphoid stem cells
Where do myeloid stem cells begin their development and what do they give rise to
in red bone marrow
give rise to : RBCs, platelets, monocytes, neutrophils, eosinophils, basophils and mast cells
lymphoid cells are found in where and give rise to what
begin development in red bone marrow but complete it in lymphatic tissues.
give rise to lymphocytes and natural killer cells
during hemopoiesis some of the myeloid stem cells differentiate into
progenitor cells
progenitor cells
no longer capable of reproducing themselves
committed to give rise to more specific elements of the blood
precursor cells
also known as blasts, developed into actual formed elements of blood
recognizable microscopic appearances
several hormones called what regulate the differentiation proliferation of particular porgenitor
hemopoietic growth factors
what increases the number of RBC precursors
erythropoietin (EPO)
EPO is produced by
cells in the kidneys that lie between the kidney tubules (peritubular interstitial cells)
what is a hormone produced by the liver that stimulates the formation of platelets from megokarocytes
thrombopoietin (TPO)
What small glycoproteins regulate development of different blood cell types
cytokines
