271b intro to hem cancer

Question 1

Leukemia (first aid) and difference between acute and chronic?

Answer 1

Lymphoid or myeloid neoplasms of WBCs with widespread involvement of bone marrow. Tumor cells are usually found in peripheral blood.

acute - progenitor cells (AML, ALL), more aggressive

chronic - mature cells (CML, CLL), less aggresive

Question 2

Lymphoma (first aid)

Answer 2

Discrete tumor masses arising from lymph nodes. Presentations often blur definitions (ie may be in BM).

Question 3

hematopoiesis for lymphoid cells? myeloid cells?

Answer 3

HSC –> common lymphoid progenitor –> NK, T, B cells

HSC –> common myeloid progenitor –> RBCs, platelets, mast cells, PMNs, etc