1st Exam

Question 1

Extent of solubility of a substance in a specific solvent is measured as

Answer 1

Saturation concentration

Question 2

Results when the simultaneous and opposing processes of dissolution and phase joining proceed at a constant rate

Answer 2

Equilibrium solubility

Question 3

Standard technique to determine thermodynamic aqueous compound solubilty

Answer 3

Shake Flask Method

Question 4

Factors affecting solubility

Answer 4

NHSSSPP

Question 5

Examples of particle size reduction

Answer 5

Micronization and sprayd drying

Question 6

Rely upon mechanical stress to disaagregate active compound

Answer 6

Particle Size Reduction

Question 7

Physical means to improve solubility

Answer 7

PDMC

Question 8

Chemical ways to improve solubiltiy

Answer 8

pBDCS

Question 9

Refers to a group of solid products consisting of at least two different components, a hydrophilic matrix and hydrophobic drug

Answer 9

Solid Dispersion

Question 10

Used to prepare fast release solid dispersion dosage forms

Answer 10

Hot-Melt Method

Question 11

Advantage is the use of a lower temperature

Answer 11

Solvent Evaporatiog method

Question 12

Same as fusion method but with intense mixing of the components

Answer 12

Hot-Melt Extrusion

Question 13

Biphasic system consisting of nano sized drug particles stabilized by surfactants for either topical and oral use or parenteral and pulmonary administration

Answer 13

Nanosuspension

Question 14

Applied to poorly soluble drugs that are insoluble in water and oi

Answer 14

Nanosuspension

Question 15

Types of nanosuspension

Answer 15

PMHC

Question 16

Suspension is prepared using high-sheer media filling

Answer 16

Media filling

Question 17

Suspension of a drug and surfactant is forced under pressure through a nanosized aparture valve of a high pressure homogenizer

Answer 17

High Pressure Homogenizer

Question 18

Technique in which precipitated particle suspension is homogenized which preserves the particle size

Answer 18

Combined precipitation and homogenization

Question 19

Ibuprofen is BCS class?

Answer 19

2

Question 20

Characteristics of a well designed drug product

Answer 20

1. Precise dose in each dosage form
2. Working according to a prescribed regimen
3. Physically stable and appealing
4. Clearly labeled with storage conditions and expiration date

Question 21

Do not possess dissociable ions, freely soluble in in water

Answer 21

Non electrolyte

Question 22

Composed of metal ions and electronegative elements

Answer 22

Inorganic acids bases and salts

Question 23

Majority of the pharmaceutical and medicinal agents

Answer 23

Organic acids and bases

Question 24

Best describe acid-base behavior

Answer 24

pKa and pH

Question 25

For systemic infections, weak acid, pKa of 6.3, crystallize in low pH --> kidney damage

Answer 25

Sulfadiazine

Question 26

Weak acid, pKa of 5.0. For UTI

Answer 26

Sulfisoxazole

Question 27

Acidic, COOH group attached to the bicyclic ring called cephem

Answer 27

Cephalosporin

Question 28

Instability of B lactam is the reason why it is poorly absorbed from the GI tract, IM for systemic infections

Answer 28

Cefoxitin

Question 29

Contains and amino group at the cephalosporin side chain, resistant to acid, for UTI

Answer 29

Cefalexin

Question 30

Tropine ester of racemic tropic acid, weak base because tertiary amine group

Answer 30

Atropine

Question 31

Display both basic and acidic characteristics

Answer 31

Amphoteric Drugs

Question 32

if pKa > pKb of basic group, ampholytes are.....

Answer 32

Ordinary ampholytes

Question 33

pKa

Answer 33

Zwitterionic

Question 34

Capable of donating more tha proton

Answer 34

Polybasic Acids

Question 35

Capable of accepting two or more protons

Answer 35

Polyacidic bases

Question 36

Mixtures of weak acid and its salt or weak base and its conjugate acid

Answer 36

Buffer

Question 37

Effectiveness of a buffer in minimizing pH change

Answer 37

Buffer capacity

Question 38

Process molecules undergo when they are transferred from the solid to the dissolved state

Answer 38

Dissolution

Question 39

Reflects the effect of solubility and particle size of the drug raw material

Answer 39

Dissolution

Question 40

Reflects the effect of formulation and manufacturing process variables

Answer 40

Disintegration

Question 41

For non oral dosage forms

Answer 41

Drug release

Question 42

Routinely used for QC and R and D

Answer 42

Dissolution

Question 43

Noyes whitney

Answer 43

Dm/dt=DA(Cs -C)/h

Question 44

Compendial buffers

Answer 44

pH = 1.2-6.8

Question 45

Factors influencing in vitro

Answer 45

PPC

Question 46

Factors influencing invivo

Answer 46

VpCHT

Question 47

Volume of fasted stomach

Answer 47

20-50mL

Question 48

Capacity of human stomach

Answer 48

1-1.6 L

Question 49

Fasted small intestine volume

Answer 49

120-350 mL

Question 50

Fed state of small intestine

Answer 50

1.6 L

Question 51

Fluid flow volume in the intestines

Answer 51

9L

Question 52

pH of gastric juice of fed stomach

Answer 52

Up to 5

Question 53

pH of gastric juice of fasted stomach

Answer 53

1.5-2.9

Question 54

pH of fasted small intestine

Answer 54

6-7.1

Question 55

pH of fed small intestine

Answer 55

5.5-6.5

Question 56

Steps in dissolution test

Answer 56

AMDSFSC

Question 57

Preparation of medium

Answer 57

Method of Deaeration Heat 41 degC Sonicate Filter using 0.45 um or less

Question 58

Name all apparatus with number

Answer 58

``` 1- rotating basket 2- paddle assembly 3- reciprocating cylinder 4- flow through cell 5-paddle over disk 6- rotating cylinder 7- reciprocating holder ```

Question 59

First line apparatus in product development of controlled release preparationg

Answer 59

Reciprocating cylinder

Question 60

For testing of products of poorly soluble drugs and chewable tablets, prevent cone formation

Answer 60

Reciprocating cylinder

Question 61

For IR tablets and sugar coated tablets; suppositories, soft gelatin capsules semisolids powders granules and implants

Answer 61

Flow-through Cell

Question 62

Specifically useful for transdermal patch

Answer 62

Rotating cylinder

Question 63

Proposed apparatus 8

Answer 63

Franz diffusion cell/vertical diffusion cell

Question 64

Property of a solid, liquid or gaseous solute to dissolve in a solid, liquid or gaseous solvent to form a homogenous solution

Answer 64

Solubility