Micromeritics

Question 1

Science and technology of small particles

Answer 1

micromeritics

Question 2

unit of measurement of micromeritics

Answer 2

micrometer

Question 3

T/F smaller particle size –> intimate contact of drug and dissolution medium –> inc solubility and dissolution

Answer 3

T

Question 4

Applications of micromeritics

Answer 4

Release and dissolution, Drug Absorption and action, Physical stability, Dose uniformity

Question 5

T/F Inc solubility and dissolution decreases rate of absorption and slow onset of action

Answer 5

F increases and fast

Question 6

T/F smaller particles increase stability

Answer 6

T

Question 7

Methods of determining particle size

Answer 7

Optical microscopy, feret’s diameter, martin’s diameter, projected area diameter, sieving, sedimentation, particle volume measurement

Question 8

T/F optical microscopy provides 3D images

Answer 8

F

Question 9

particle size of optical microscopy

Answer 9

0.2-100 um

Question 10

particle size of sieving

Answer 10

40-9500 um

Question 11

T/F increasing mesh number decreasing particle sze

Answer 11

T

Question 12

Apparatus used in Sedimentation

Answer 12

Andreasen apparatus

Question 13

particle size of sedimentation

Answer 13

0.8-300 um

Question 14

Law followed by sedimentation

Answer 14

stoke’s law

Question 15

Terminal settling velocity of particles through a liquid medium in a gravitational centrifugal movement using Andreasen Apparatus

Answer 15

Sedimentation

Question 16

Size of particle size measurement

Answer 16

0.5-300 um

Question 17

Powder is suspended in an electrolyte solution and is made to flow thru a short insulated capillary section between 2 electrodes and the resistance of the system is measured

Answer 17

Particle size measurement

Question 18

Machines in particle volume measurement

Answer 18

Coulter-Counter, HIAC/Royco, Gelman Counter

Question 19

properties that are defined individually

Answer 19

Fundamental properties

Question 20

properties that are dependent on the fundamental properties

Answer 20

derived properties

Question 21

examples of derived properties

Answer 21

density, porosity, packing arrangement, flow properties

Question 22

examples of fundamental properties

Answer 22

size and shape, size distribution

Question 23

difference between the bullk volume and true volume

Answer 23

void volume

Question 24

measure of the void volume in a powder material

Answer 24

porosity

Question 25

total volume of the material

Answer 25

bulk volume

Question 26

T/F bulk volume is measured with a beaker

Answer 26

F. grad cyl

Question 27

equal to true volume + interparticle pores

Answer 27

specific granule volume (Vg)

Question 28

equal to true volume + interparticle pores + spaces between pores

Answer 28

specific bulk volume (Vb)

Question 29

excludes the volume of pores and interparticle spaces

Answer 29

true density or absolute density

Question 30

instrument to measure true or absolute density

Answer 30

helium densitometer

Question 31

includes the pore volume but excludes the interparticle spaces

Answer 31

apparent or envelope density

Question 32

apparent or envelop density is based on

Answer 32

liquid displacement

Question 33

includes both pore volume and interparticle spaces

Answer 33

Bulk density

Question 34

describes the packing of particles or granules

Answer 34

Bulk density

Question 35

Method I for Bulk density

Answer 35

Graduated cylinder

Question 36

Method II for Bulk density

Answer 36

Volumeter

Question 37

example of volumeter

Answer 37

scott volumeter

Question 38

Method III for Bulk density

Answer 38

Vessel

Question 39

# Define bulk density: 1. increase granule size | 2. less spherical

Answer 39

1. decrease | 2. decrease

Question 40

T/F an increase in BD will cause an increase in porosity hence increasing interparticle contact and inc cohesion

Answer 40

F. decrease porosity dapat

Question 41

reflects maximum packing density of a powder achieved under the influence of well-defined, externally applied force

Answer 41

Tapped density

Question 42

ease with which a powder will flow under a set of conditions

Answer 42

Powder flowability

Question 43

T/F angle of repose is an intrinsic property

Answer 43

F

Question 44

T/F angle of repose depends upon the method used

Answer 44

T

Question 45

Characteristic of the internal friction or cohesion of the particles

Answer 45

Angle of repose

Question 46

T/F if powder is very cohesive, the heap is characterized by only one angle of repose

Answer 46

F. >1

Question 47

measures the angle of pile of material at rest and gives some recognition of a powders ability to flow

Answer 47

angle of repose

Question 48

T/F rough and more irregular surface of particles --> lower angle of repose

Answer 48

F. Higher dapat

Question 49

T/F compressibility index is an intrinsic property

Answer 49

F

Question 50

measures propensity of a powder to be compressed

Answer 50

Compressibility facto

Question 51

T/F Higher Carr's compressibility index, more free flowing

Answer 51

F

Question 52

T/F higher hausner ratio, less free flowing

Answer 52

T

Question 53

more cohesive powders have hausner ratio greater than ___

Answer 53

1.6

Question 54

T/F coarse spheres have high interparticle friction

Answer 54

F low

Question 55

T/F free flowing powders have closer values of bulk and tapped densities

Answer 55

T

Question 56

give 2 manufacturing problems

Answer 56

uneven powder flow; caking; segragation in blending; transfer of powders thru hoppers

Question 57

Stages in tablet formation

Answer 57

Die filling, Tablet formation, Tablet rejection

Question 58

Components of a tablet press

Answer 58

HDPCFUD

Question 59

pharmaceutical process that converts a mixture of powders, which have poor cohesion, into aggregates capable of compaction

Answer 59

Granulation

Question 60

T/F Granulation prevents seggragation

Answer 60

T