2 - Homeostasis Flashcards

(53 cards)

1
Q

Homeostasis concept

A

Homeostasis is the maintenance of a stable internal environment within tolerable limits, despite external changes

Essential for physiological functions such as temperature regulation, pH balance, and ion concentrations

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2
Q

Regulated variable

A

directly controlled or regulated and for which there are specific sensors that monitor any changes

(eg. Body temperature which is specifically monitored by peripheral and central temperature receptors)

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3
Q

Unregulated variables

A

contribute to control of process but don’t have specific sensors

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4
Q

Negative feedback

A

system that detects deviations from a set point and initiates corrective actions (eg. Body temperature regulation)

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5
Q

Positive feedback

A

amplifies changes until a specific endpoint is reached (eg. Childbirth contractions) / there must be an end point at which the systems switched off and homeostasis

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6
Q

Factors influeincing homeostasis

A

Genetics / nutrition / physical activity / mental health / environmental exposure

Physically activity - effects gas usage and production —> CO2 production will affect pH and ATP use

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7
Q

Failure of homeostasis

A

Deficiency - lack of essential elements impairs biological processes

Toxicity - excess elements can disrupt cellular function

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8
Q

Components of cell membrane

A

Phospholipids bilayer

Proteins

Cholesterol

Carbohydrates

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9
Q

CM structure - phospholipids bilayer

A

hydrophilic heads face outward; hydrophobic tails face inward

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10
Q

CM structure - proteins

A

embedded in the membrane for transport, signalling, and structural support

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11
Q

CM structure - cholesterol

A

Provides membrane fluidity and stability

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12
Q

CM function

A

Controls the movement of substances in and out of the cell

Maintains homeostasis by regulating internal conditions

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13
Q

CM - Protein pores

A

Beta pleated sheets

Form a pore through the membrane (can be selective or non-selective)

Can also be known as leakage channels

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14
Q

Passive transport

A

No ATP required

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15
Q

Simple diffusion

A

movement of molecules (e.g., O₂, CO₂) from high to low concentration

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16
Q

Facilitated diffusion

A

movement via protein channels or carrier proteins (e.g., glucose transport)

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17
Q

Osmosis

A

diffusion of water through a semi-permeable membrane driven by solute concentration

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18
Q

RBC - why cant they withstand pressure increase

A

bursts due to lack of cell wall

(cant withstand the pressure increase when water moves in from hypotonic solution)

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19
Q

Isotonic

A

Equal concentration inside and outside

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20
Q

Hypertonic solution

A

Water moves out of the- shrivelled

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21
Q

Hypotonic solution

A

Water moves in - burst or swell

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22
Q

What’s transpiration controlled by

A

Concentration of a sciatic acid

23
Q

Living in saline water - impermeable membranes

A

Prevents excess water loss

24
Q

Marine organisms tend to be…

25
How do marine mammals have efficient kidneys
gain NaCl from breathing and drinking (pump excess Cl- out)
26
How are sharks different
Accumulate urea so hyperosmotic
27
Living in fresh water - hypertonic
Face constant influx of water (or loss of ions)
28
Living in fresh water - impermeable surface
Prevent excess water coming in Water permeability is permitted to only a limited number of specilised cells (all other cells are maintenance in isotonic solution)
29
Living in freshwater - how to maintain osmotic balance
Use ATP driven Cl- pumps into the cell
30
Primary active transport
direct use of ATP (eg. Sodium-potassium pump moves Na+ out and K+ in)
31
Secondary active transport
uses energy from ion gradients (eg. Na+ glucose symporter)
32
Transporters - uniporters
move a single molecule (eg. Glucose transporter)
33
Transporters - symporters
move 2 molecules in the same direction (eg. Na+ and glucose) (co-transport)
34
Transporters - antiporters
move 2 molecules in opposite directions (eg. Na+ Ca2+ exchanger)
35
Factors influencing diffusion rate (5)
Concentration gradient Temperature Surface area Membrane permeability Molecule size
36
Concentration gradient
Greater difference = faster diffusion
37
Temperature
higher temperature = increased kinetic energy = faster diffusion
38
Surface area
Larger area = more diffusion
39
Membrane permeability
lipid-soluble molecules diffuse more easily
40
Molecule size
smaller molecules diffuse faster
41
Active transport mechanisms
Definition: Movement of molecules against the concentration gradient using energy (ATP) Sodium-Potassium Pump (Na⁺/K⁺ ATPase)
42
Active transport - where is it useful
Maintains resting membrane potential in nerve cells Calcium Pump: Regulates Ca²⁺ levels in muscle cells
43
Vesicle transporters (packages)
Lipid bilayers / allow separation from the cytosol Involved in metabolism / transport / enzyme storage / buoyancy control Eg. Vacuoles (plant cells) / lysosomes / transport vesicles / secretory vesicles / gas vesicles (bacteria, planktonic)
44
Macromolecular Transport Mechanisms (4)
Endocytosis Phagocytosis Pinocytosis Receptor-Mediated Endocytosis
45
Endocytosis
Cell engulfing substances
46
Phagocytosis
engulfing large particles (e.g., immune cells ingesting bacteria)
47
Pinicytosis
uptake of fluids and dissolved substances
48
Receptor-Mediated Endocytosis
selective uptake via receptors (e.g., LDL cholesterol intake)
49
Exocytosis definition
Releasing substances outside of the cell
50
Exocytosis (2)
Constitutive exocytosis Regulated exocytosis
51
Constitutive exocytosis
Continuous vesicle fusion for membrane protein delivery
52
Regulated exocytosis
Triggered by signals (eg. Neurotransmitter release from neurones)
53
Lysosomes Function
Waste disposal system (acid hydrolyse enzymes) Endocytosis (endosomes - pH 6.2-6.3 / recycling of receptor)