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FCP week 2 > 2- Pharmacology of ectoparasitic control > Flashcards

2- Pharmacology of ectoparasitic control Flashcards

1
Q

Name the 6 main groups of ectoparasite control

A

Nicotinic acetylcholine receptor stimulants (Neoniatinoids)

Cholinesterase inhibitors (organophosphate)

GABA inhibitors (Phenylpyrrazoles)

GABA & Chloride channel inhibitors (Isoxazolines)

Chloride Channel stimulator (Macrolyclic lactones)

Sodium channel stimulant (Pyrethroids)

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2
Q

What drug group does Imidacloprid belong to

A

Neonicatinoids

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3
Q

Imidacloprid:
What drug group? What pathway does it act on? & What is it used for? Is it absorbed systemically?

A

Neonicatinoids = Acting as a nicotinic Ach receptor stimulant

Licensed for fleas in small animals
Not absorbed systemically

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4
Q

Name drugs that belong to the Neonicatinoids

A

Imidacloprid
Nitenpyram
Dinotefuran

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5
Q

A organophosphate is a …..

A

Cholinesterase inhibitor

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6
Q

What drug group does diazinon belong to?

A

Organophosphates

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7
Q

Why has the use of organophosphates been reduced

A

use greatly reduced due to neurotoxicity concerns
Was in sheep dip

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8
Q

Give a drug example of a GABA inhibitor

A

Fipronil (frontline)

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9
Q

A pehnylpyrrazoles is a ……… & acts against what parasites?

A

GABA Inhibitor
fleas & ticks (& chewing lice in dogs)
not absorbed systemically

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10
Q

Safety concern on fipronil

A

Toxic to rabbits

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11
Q

Isoxazolines are a….. & what parasites do they act on?

A

GABA & Chloride channel inhibitor

Fleas & ticks
rapid onset of action
absorbed systemically

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12
Q

Using isoxazolines in what type of patient is contraindicated

A

Animals having seizures

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13
Q

Give 2 examples of a isoxazolines

A

Fluralaner (bravecto)
Sarolaner
Afoxolaner
Esafoxolaner
Lotilaner

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14
Q

Macrocyclic lactones are a ……

A

Chloride channel stimulator

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15
Q

What are the 2 groups of macrocyclic lactones?

A

Ivermectin’s & Milbemycins

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16
Q

What is the safety concern regarding macrocyclic lactones?

A

Neurotoxicity if MDR1 gene mutation (seen in collies)
ivermectin ix toxic to chelonians

17
Q

Moxidectin & milbemycin oxide is what type of drug?

A

Milbemycin = macrocyclic lactone = Chloride channel stimulator

18
Q

What animal is ivermectin toxic too?

A

Chelonians

19
Q

Pyrethroids are a …..

A

Sodium channel stimulant

20
Q

Give 2 examples of pyrethroids

A

Permethrin
Cypermethrin
Deltamethrin
Flumethrin

21
Q

Pyrethroids are toxic to what species?

A

Cats & Aquatic life

22
Q

3 modes of action of insect growth regulators

A

Juvenile hormone analogues
Chitin synthesis inhibitors
Triazine derivatives

23
Q

What class of drugs also act as repellents?

A

Pyrethroids

24
Q

How do neurotoxins work as part of ectoparasitic control

A

act on parasite CNS synapses, axons or neuromuscular junctions —> spastic or flaccid paralysis

FCP week 2 (40 decks)

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