2. Targets and Treatments Flashcards
(24 cards)
What are COX-2 selective NSAIDs
Celecoxib, etoricoxib
Adverse effects of NSAIDs
CVD, Renal impairment, GI ulceration - less with COX2
Side effects of GCs
Osteoporosis, infection, GI ulceration with NSAID, weight gain and diabetes, hypertension
DNA synthesis inhibitors
Methothrexate, axa, leflunomide, mycophenylate, cyclophosphamide
CNI
Ciclosporin
Lysosome inhibitor
Hydroxychloroquine
NF-kB inhibitor
Sulfsalazine
TNF inhibitors - and what are they inidcated inn
Inflximab, adlimumab
RA, PsA, AxSPa
Decoy receptor for TNFa
Etanercept
What does Tocilizumab do and what is it licensed for
Targets IL-6R and is licensed for RA and GCA
What inhibitor is used for EGPA
IL-5 inhibitor
Mepolizumab
What is IL-1 inhibitor licensed for
Still’s disease, familial fever Sx and acute gout
Canakinumab- Il-1B mab
Anakinra- IL-1 decoy R
What is indicated for PSA and AxSp
IL-12/23 like ustekinumab ( also for IBD), IL-23 (rheum diseasse) and IL-17
What is abatacept
Fusion protein of CTLA4 and IgG1, decoy receptor for B7- inhibits inflam respose
For RA and PsA
What is Rituxumab indicated for
RA, ANCA vasculitis
What is belimumab indicated for
SLE
What are JAK inhibitors inidcated for
RA, PsA and AxSpA
What is PDE4 inhibited for and how does it work
PsA and Psoriasis, Apremilast increases cAMP and increases PKA, reducing inflamm cytokines
What are adverse effects of most cDMARDs
Leukopenia, thrombocytopenia, abnormal LFTs
What common cDMARD doesnt need montioring
Hydroxycloroquine
What causes renal impairment
Cyclosporin
What causes retinopathy
Hydroxycloroquine
what increases risk of malignancy
Anti-TNF and JAK inhibitor
