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[OS 215] OB Patho E2 > 2014 > Flashcards

Flashcards in 2014 Deck (61)
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1

Which of the following tissues will be likely to be negative for estrogen receptors?

A. normal breast duct

B. lactating duct

C. hyperplastic duct

D. poorly differentiated ductal carcinoma

D

2

Which of the following has the worst prognosis?

A. Ductal carcinoma, no specific type

B. Mucinous carcinoma

C. Tubular carcinoma

D. Lobular carcinoma

A

3

The following carcinomas involve tubular duct lobular units except for:

A. Lobular carcinoma

B. Invasive ductal carcinoma

C. Angiosarcoma

D. Metaplastic carcinoma

C

4

Tissue fat necrosis of breast tissue can be clinically misdiagnosed as neoplasia

A. True

B. False

NA

5

Seen in autoimmune mastitis:

A. FORGOT

B. Dense collagenous stroma

C. Perivascular inflammation

D. Predominance of lymphatic infiltrates

NA

6

The characteristic dyshesive loose pattern sometimes seen in lobular carcinoma is due to the lack of:

A. Estrogen

B. Human epidermal growth factor

C. E-cadherin

D. P63

C

7

The intergrity of the myoepithelial cells defines whether a breast carcinoma is in situ or invasive

A. True

B. False

A

8

Microinvasive carcinoma is diagnosed only when the invasive foci measures 1mm or less and the rest of the lesion will show only in situ lesion. There should be no other invasive foci measuring more than 1 mm.

A. True

B. False

A

9

A metaplastic carcinoma will have all of the following features except

A. a malignant epithelial component

B. a metaplastic epithelial component

C. a metaplastic stromal component

D. a benign, dense stromal component

B

10

Characteristic of classic medullary carcinoma except:

A. Presence of recognizable ducts

B. Pleiomorphic cells

C. Lymphoplasmocytic changes

D. Estrogen receptor negative

C

11

The most important prognostic factor in breast carcinoma is

A. status of axillary lymph nodes

B. histologic type of tumor

C. multifocality

D. family history

A

12

True of sporadic breast cancers except

A. Younger age of menarche

B. Estrogen dependent

C. Affects older age group

D. One has increased risk if paternal grandmother has breast CA

D

13

Hereditary breast cancer is commonly associated with the following except

A. younger age group

B. more aggressive than sporadic breast cancer

C. negative for estrogen and progesterone receptors

D. most common is medullary carcinoma

C

14

Which of the following has the best prognosis?

A. mucinous carcinoma

B. invasive papillary carcinoma

C. well-differentiated invasive ductal carcinoma

D. microinvasive ductal carcinoma

D

15

Difference between phyllodes and fibroadenoma

a) Size of tumor. Phyllodes larger than FA

b) Border. FA has well defined border

c) Stromal cell. Phyllodes have more cellular stroma

d) Ductal patterns. FA has pericanalicular growth pattern

C

16

Not a fibroepithelial lesion

A. Fibroadenoma

B. Phylloides tumor

C. Spindle cell CA

C

17

Metastatic foci from a malignant phylloid tumor arise from which part of the primary lesion?

A. Stroma

B. Ducts

C. Both Ducts and Stroma

D. None of the above

A

18

Bloom and Richardson grading includes the following except:

a. Mitotic count

b. Degree of duct formation

c. Nuclear grade

d. Size of tumor

D

19

Which of the following is NOT a morphologic pattern of ductal carcinoma in situ?

a. Solid

b. Cribriform

c. Papillary

d. Metaplastic

D

20

This type of DCIS present with cookie cutter shapes and thick bridges

a. Solid

b. Mucinous

c. Cribriform

d. Papillary

C

21

Lobular carcinoma can metastasize to the following organs EXCEPT:

a. Leptomeninges

b. Female genital tract

c. Gastrointestinal tract

d. Thyroid gland

D

22

Seen in fat necrosis except:

a. foamy macrophages

b. giant cell

c. lympholytic infiltrates

d. dense fibrotic stroma

C

23

Poorly differentiated ductal carcinomas arise en toto from well differentiated breast carcinomas

A. True

B. False

B

24

Fibroadenoma can have hyalinized stroma and atrophic ducts in postmenopausal women.

A. True

B. False

A

25

A ductal carcinoma in situ will have myoepithelial cells in:

A. the fibrovascular core only

B. both the fibrovascular cores and periphery of the lesion

C. the periphery of the duct

D. the endothelial lining of the blood vessels

C

26

Not true of lobular neoplasia:

A. arise from lobular duct terminal units

B. positive for e-cadherin

B

27

This inflammatory lesion is characterized by keratin plugs in the nipple

A. duct ectasia

B. lymphocytic mastopathy

C. squamous metaplasia of the lactiferous duct

D. Paget’s disease

C

28

Which of the following morphology is not associated with in situ ductal lesions?

A. cribriform

B. medullary

C. papillary

D. micropapillary

B

29

What are the 2 most important prognostic factors for invasive ductal carcinoma?

A. lymph node status and tumor size

B. tumor size and mitotic count

C. sentinel lymph node status and tumor metastasis

D. tumor size and distant metastasis

A

30

Invasive Papillary Carcinoma in the absence of myoepithelial cells.

A. Fibrous _________ and p_______

B.

C. Periphery of the cells

D. Endothelial lining of the blood vessels

NA