Lecture 2 - Cells and Tissues of the Immune System Flashcards
Does lymph circulate like blood?
No. It is an open-ended system
Parts of a lymph node 1) 2) 3) 4) 5)
1) Capsule
2) Cortex
3) Follicle
4) Paracortex
5) Medulla
Which cell is predominant in the paracortical areas of lymph nodes?
T cell
Which cell is predominant in the follicular areas of lymph nodes?
B cell
Which cell type is predominant in the medullary cords of lymph nodes?
Macrophages and dendritic cells
Does the spleen receive lymph?
No.
Only receives blood.
Structure of white pulp of spleen
1)
2)
3)
1) Central arteriole surrounded by periarteriolar lymphoid sheath
2) Germinal centres sit beside periarteriolar lymphoid sheath
3) Germinal sheath is surrounded by B cell corona and marginal zone
What happens in the red pulp of the spleen?
Old erythrocytes are digested by macrophages
Types of granulocytes
1)
2)
3)
1) Basophils
2) Eosinophils
3) Neutrophils
Function of basophils
1)
2)
1) Promote allergic response
2) Promote anti-parasitic immunity
Where are neutrophil granulocytes normally found?
In blood
In infected tissue
Where are neutrophils produced?
Bone marrow
How long do neutrohphils live?
7-10 days
Neutrophil disorders
1)
2)
1) Myeloid leukaemias
2) Chronic granulomatous disease
Why do eosinophils stain purple with eosin stain?
Granules contain arginine-richbasic protein
