Drug Mechanism of Action -- Tracte

Question 1

What drugs function by DIRECTLY blocking the action potential conductance?

Answer 1

Only one listed:

lidocaine

blocks Na channels

Question 2

What drugs function through adding to the synthesis capabilities for a neurotransmitter?

Answer 2

L-DOPA or levodopa to increse DA

Question 3

What drugs act on the storage of neurotransmitters?

Answer 3

reserpine depletes NE storage

Question 4

glutamate as a neurotransmitter

Answer 4

glutamate is a stimulatory NT postsynaptically

associated with hierarchical pathways

Three receptors: NMDA, AMPA, and Kainic Acid

Question 5

glycine as a neurotransmitter

Answer 5

inhibitory neurotransmitter of spinal cord and brain stem

receptor is permiable to Cl-

Question 6

Acetylcholine as a neurotransmitter

Answer 6

synthesized in the Basal nucleus of Meynert

acts on two classes of receptors

1. Nicotinic (Na channel)
2. Muscarinic (GPCR) – decresing cAMP (MEMORY!)

Question 7

Dopamine as a neurotransmitter

Answer 7

synthesized in the SNc and ventral tegmental area

Two primary groups of receptors:

1. D1 – Gs protein –> increases [cAMP]
2. D2 – Gi protein –> suppresses [cAMP] and is inhibitory

Question 8

NT for motor activation?

Answer 8

gluatmate

Question 9

NT for motor inhibition?

Answer 9

GABA

glycine

NE

Question 10

NT that causes motor stimulation through disinhibition?

Answer 10

DA

Question 11

NT associated with memory?

Answer 11

ACh

Question 12

NT associated with psychoses?

Answer 12

serotonin and

5-HT₂ receptors

Question 13

NT associated with pain?

Answer 13

opioids are inhibitory NT, so problems can result in pain