2.1 A time line of genetics: from Darwin to DNA Flashcards

1
Q

1853

A

Darwin publishes the ‘origin’

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2
Q

1853 - 1866

A

Mendel formulates laws of inheritance

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3
Q

1869

A

Friedrich Mescher isolates nucleic acids (‘nuclein’) from pus

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4
Q

1885

A

Strasburger and Flemming describe chromosomes

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5
Q

1900

A

Mendel’s work rediscovered

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6
Q

1902

A

Sutton + Bover’s chromosome theory of heredity

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7
Q

1904

A

Morgan’s experiments with Drosophila reveal mutations

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8
Q

1909

A

Johansson introduces the term ‘gene’

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9
Q

1928

A

Griffith discovers ‘transforming principle’ in bacteria

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10
Q

1944

A

Avery et al identify DNA as the ‘transforming principle’

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11
Q

1953

A

Hershey and Chase experiments:
DNA as the genetic material in phage T2

Watson and Crick propose a structure for DNA

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12
Q

1970s

A

Fred Sanger develops dideoxy sequencing

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13
Q

1972

A

Paul Berg constructs 1st recombinant DNA

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14
Q

1981

A

Human mtDNA sequenced

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15
Q

1986

A

Kary Mulls develops PCR

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16
Q

1991

A

Human genome project proposed

17
Q

2001

A

release of draft human genome sequence

18
Q

2004

A

‘complete’ human genome sequence

19
Q

2010

A

Neanderthal genome sequuenced

initial phase of 1000 genomes project published

20
Q

2016

A

1000s of genomes available -> Cost of genome sequencing now ~£3K

21
Q

The near future

A

£1K genomes -> personalised genomics