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Neuroscience > Neuropharmacology > Flashcards

Neuropharmacology Flashcards

0
Q

Name a common SSRI

A

Fluoxetine

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1
Q

Name the 3 classes of antidepressants

A

Tricyclics
SSRIs
SNRIs

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2
Q

Bioavailability

A

Fraction of drug absorbed into systemic circulation

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3
Q

What route gives 100% bioavailability?

A

IV

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4
Q

Volume if distribution calculation

A

= total amount of drug /

conc in plasma

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5
Q

Why part if the brain is outside the BBB. What drug can act in it as it’s too big to cross the BBB?

A

Pineal gland

Melatonin

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6
Q

CL =

A

Vd ❌ kel

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7
Q

What substance involves zero order elimination?

A

Alcohol

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8
Q

Through what are drugs excreted?

A 
Kidneys
Lungs
Bile
Sweat
Milk
Saliva
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9
Q

Is lithium metabolised in the body?

A

No. Relies entirely on renal clearance

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10
Q

What can affect the renal clearance of lithium?

A 
Dehydration
Alcohol
Non sodium sparing dietetics
Polyuria
Renal insufficiency
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11
Q

Does lithium have a wide or narrow therapeutic window?

A

Narrow

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12
Q

When do antidepressants kick in fully?

A

6-8 weeks

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13
Q

Tolerance

A

Desensitisation of target receptors after repeated administration

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14
Q

Sensitivity if receptors

A

Usually result of

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15
Q

Where is NA made?

A

Locus coeruleus

16
Q

Where is serotonin made?

A

Raphe nuclei?

17
Q

Where is dopamine made?

A

Substantial nigra

18
Q

Psychosis

A

An altered way of perceiving the world

Loosing touch with reality

19
Q

Name the 3 dopamine tracts

A

Nigrostriatal
Mesocortical & mesolimbic
Tuberounfundibular

20
Q

Which tract controls prolactin release?

A

Tuberounfundubular

21
Q

What’s the precursor if serotonin?

A

Tryptophan

22
Q

Dopamine precursor?

A

Tyrosine

23
Q

NA precursor?

A

Dopamine

24
Q

ACh precursor?

A

Choline

25
Q

Which NT is important in Altzeimer’s?

A

ACh

26
Q

Serotonin is widely implicated in what diseases?

A

OCD
Panic disorders
Schizophrenia

27
Q

Where are glutamate and GABA contained in?

A

Astrocytes & interneurons

28
Q

What happens to glutamate in schizophrenia and mood disorders?

A

⬆️

29
Q

What happen to GABA in epilepsy & schizophrenia?

A

⬇️

30
Q

What ions does the GABA receptor allow into cells?

A

Cl-

31
Q

What benzodiazepines are used for insomnia?

A

Temazepam & Fluroxepam?

32
Q

Tricyclics inhibit the reuptake of…..

A

Serotonin & NA

33
Q

Anti adrenergic side effects

A

Postural hypotension
Arrhythmia
Tachycardia
V dangerous in OD

34
Q

Anti cholinergic side effects

A 
Blurred vision
Tachycardia
Urinary retention
Constipation
Dehydration
35
Q

Dopamine blockade side effects

A 
Parkinsonism 
Acute dystonias
Akithisia
Tardive dyskinesia
Hyperptolactinaemia
Anhedonia
36
Q

Anhedonia

A

Can’t enjoy things you used to

Neuroscience (20 decks)

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