2.14 Flashcards
(16 cards)
Pharmaceutical Aspects
Drug is ready for absorption
“circulatory system”
Pharmacokinetic Aspects
Absorption, Distribution, Biotransformation, Elimination
“What they body does with the drug”
Pharmacodynamic Aspects
Actions to alter cellular-physiological systems
“What the does the drug do?”
Therapeutic Aspects
Responses that provide therapeutic and undesirable (“side effects”) actions
5 Aspects of the Receptor Theory
- Observations of the chemical and physiological specificity
- Genes encoding receptor proteins have been cloned and sequenced based
- Quantitative relationship between drug dose and pharmacologic effect (dose vs concentration (heart invitro))
- Selectivity of drug action
- Pharmacologic agonist and antagonists
There is no receptor in the body that doesnt have a unique chemical in body to react with
Most drugs dont create anything new they alter communication system
What are drug receptors?
- Cell surface or intracellular regulator proteins
- Enzymes
- Structural Proteins
Effect max
Maximum response of system
EC50
Concentration at half the maximum response
Law of Mass Action
Two opposing forces: augmentation or action and inhibition
Clark’s Theory
R + L RL
Ka=?
[RL]/([R][L])
Kd=?
([R][L])/[RL]
What happens to the affinity as Kd increases?
Affinity decreases
Slow dissociation
‘Love’, high affinity
