22: Diabetic Myonecrosis - Mahoney Flashcards Preview

CS2 Exam II > 22: Diabetic Myonecrosis - Mahoney > Flashcards

Flashcards in 22: Diabetic Myonecrosis - Mahoney Deck (19):
1

A1c to blood glucose conversion

A1C x 33.3 - 86 = blood glucose level

2

What does humulin N 70/30 mean?

percent of every unit (intermediate/regular insulin)

3

what medication might cause muscle pain?

statins

4

what type of neuropathy attacks the thighs more?

diabetic amyotrophy
(proximal diabetic neuropathy)

5

what eosinophil level might indicate a parasite infection?

greater than 6%

6

what does a sed rate tell you?

marker of generalized inflammation in the body

Males: age/2 = normal sed rate

7

what would a CPK tell you?

creatinine kinase

tells if muscle tissue injury present

8

fluid looks ______ on T1 and _____ on T2

black
white/bright

9

MRI findings: ________ to muscle on T1; _________ on T2

hypointense
hyperintense

10

____ IV gadolinium on a T1 will show _________ for an abscess

dark central area surrounded by a bright brim

need to use IV gadolinium to check for abscess

11

where is diabetic myonecrosis most likely to appear?

pain and swelling in anterior thigh (80%) or calf (20%)

12

what lab markers are there for diabetic myonecrosis?

no specific laboratory marker

leukocytosis less than 10% of cases
elevated CK in 50% of cases

13

pathogenesis of diabetic myonecrosis (2)

- vascular disease (ischemia --> soft tissue swelling --> increased pressure --> decreased blood flow)
- hypercoagulability (increased factor VII activity, increased levels of tissue plasminogen activator inhibitor and thrombomodulin, impaired response of tissue plasminogen activator to venous occlusion, cases of antiphopholipid syndrome found as etiology)

14

most valuable diagnostic technique

MRI

15

treatment

self-limiting disease

supportive rest and analgesia

16

any diabetic with thigh pain and swelling -->

consider diabetic myonecrosis

17

gold standard for diagnosis

biopsy, but should be avoided due to possible complications

18

risk of recurrence

high in ipsilateral or contralateral leg

19

long term prognosis

poor

myonecrosis is a marker for significant systemic vascular complications