36/37: WBC Pathology- Fang Flashcards Preview

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Flashcards in 36/37: WBC Pathology- Fang Deck (30):
1

lymphoma v. leukemia

lymphoid neoplasms arising as discrete masses

lymphoid or myeloid neoplasms with involvement of blood and bone marrow

2

CD20 =
CD3 =

B cell marker
T cell marker

3

B cell markers

CD 19
CD 20
Lamda light chain

4

most tumors are ______ in 10-20 yo

lymphoma

5

stage = ?
single lymph node REGIONS (not nodes!) or extralymphatic site

I

6

stage = ?
two or more LN REGIONS or extralymphatic site on same side of DIAPHRAGM

II

7

stage = ?
LN REGION or extralymphatic site on both side of the DIAPHRAGM

III

8

stage = ?
disseminated or diffuse involvement of one or more extralymphatic sites

IV

9

A v. B staging of lymphoma

a- asymptomatic
b- fever, night sweats or 10% weight loss

10

what b-cell lymphomas arise from the germinal center?
mantle zone?

follicular AND burkitt

mantel cell

11

key characteristics of follicular lymphoma

middle age
widespread disease at diagnosis

peripheral and central lymphadenopathy
splenomegaly
BM 50%

12

low grade v. high grade follicular lymphoma

low- mostly centrocytes

high- greater than 15 centroblasts/hpf

13

+ = CD 19, CD 20, CD 10, Bcl-2

- = CD5 CD3

follicular lymphoma

14

key characteristics mantle cell lymphoma

50-60 yo
male
generalized lymphadenopaty with BM and liver involvement
splenomegaly 50%
lymphomatoid polyposis

15

lymphomatoid polyposis indicates...

mantle cell lymphoma

16

+ = CD 19/20, CD5, Cyclin D1

- = CD23, CD3

mantle cell lymphoma

17

three types of burkitt lymphoma

endemic/African (4-7 yo)(EBV+)(jaws, facial bones)

Sporadic (30 yo)(abdominal, ielo-cecal)

Immunodeficiency (HIV/AIDS)(nodal, bone marrow)

*all at risk for CNS involvement

18

**diffuse monomorphic infiltrate of intermediate size round to slightly irregular lymphoid cells with multiple peripherally placed nucleoli

Burkitts lymphoma

19

"starry sky pattern" or tingible body macrophages

burkitts lymphoma

20

+ = CD 10, CD19, CD 20
- = bcl-2

burkitt lymphoma

21

occur only in adults, CD52 involved in pathogenesis

adult t cell leukemia/lymphoma

mature t cell neoplasm caused by HTLV1

not common in US

22

CD4+
flower cells

adult t cell leukemia/lymphoma

23

CD 4+
cerebriform nuclei

mycosis/fungoides/sezary syndrome

skin is always involved

24

epidermal plaque phase followed by tumor phase in dermis

mycosis fungoides

25

leukemia and generalized exfoliative erythroderma simultaneoulsy

sezary syndrome

26

abrupt stormy onset likely due to mediastinal mass

Tcell ALL

27

sheets of monotonous blasts

Tcell ALL

28

CD34+
TdT+
CD1a+
cytoplasmic CD3 + (not surface CD3)

Tcell ALL

29

CD30+
ALK-1+
EMA+

ALCL

anaplastic large T cell lymphoma

30

pleiomorphic with Hallmark cells

ALCL

hallmark cells are medium sized with kidney shaped nuclei