2.2 Thrombocytopoiesis Flashcards
Marrow transit time of megakaryocyte is approx.?
5 days
In the bone marrow environment; proplatelet processes pierce through the endothelial cells, extends in the the venous blood and shed platelet
T or F
T
A single megakaryocyte may shed ___________ Platelets
2000-4000
Megakaryocyte does not go to the blood circulation instead shed itself in the EC where platelets go to the circulation
T or F
T
Platelets are anucleate cells with granular cytoplasm with 2-4 um diameter
T or F
T
Normal blood count of platelet?
150-400 x 10^9 / L
Normal blood count in platelet decreases with increasing l after 65 years of age:
Men: _______ x 10^9/L
Women: ________ x 10^9/L
a. 150 - 400, 100 - 350
b. 122-350, 140 - 379
c. 140 - 379, 122-350
d. 100 - 350, 150 - 400
b
Mean platelet Volume is?
8-10 fL
Platelets survive for ______ days in the circulation
8-9
Platelet distribution:
- ____ of platelets = in the body circulation
-____ of platelets = sequestered in the spleen
2/3
1/3
All platelets are circulating (3/3) cause by asplenic individuals causing?
a. Thrombocytosis
b. Thrombocytopenia
a
Splenomegaly/Hypersplenism which up to 90% may be sequestered
a. Thrombocytosis
b. Thrombocytopenia
b
This appears in compensation for thrombocytopenia which is a
- Large than ordinary mature circulating platelets whose MPV reaches 12-14 fL
Reticulated platelets or Stress platelets
Reticulated platelts carry free ribosomes and fragments of rough endoplasmic reticulum
T or F
T
Nucleic acid dye binds the RNA and can be detected by flow cytometry
T or F
T
