seronegative spondyloarthropathies

Question 1

psoriatic arthritis

Answer 1

joint pain and stiffness associated with psoriasis
asymmetric and patchy involvement. dactylitis (sausage fingers) and pencil-in-cup deformity on x ray. fewer than 1/3 of pts with psoriasis

Question 2

ankylosing spondylitis

Answer 2

spine and sacroiliac joint disease. see stiff spine from joint fusion (bamboo spine), uveitis, and aortic regurg

Question 3

What infections may be followed by reactive arthrits?

Answer 3

GI (shigella, salmonella, yersinia, campylobacter) or chlamydia

Question 4

What do you see in sarcoidosis?

Answer 4

widespread non-caseating granulomas and elevated serum ACE levels

Question 5

What are some symptoms in sarcoid?

Answer 5

restrictive lung disease, erythema nodosum, lupus pernio, Bell palsy, epitheliod granulomas with asteroid bodies, uveitis, and hyper calcemia (d/t vitamin D activation in macrophates)

Question 6

Polymyalgia rheumatica. what is it associated with?

Answer 6

pain and stiffness in shoulders and hips, often with fever, malaise, and weight loss. no weakness. associated with giant cell arteritis.

Question 7

Findings and treatments for polymyalgia rheumatica

Answer 7

incr. ESR, incr CRP, normal CK. give low-dose corticosteroids

Question 8

With what other problem is myasthenia gravis often associated?

Answer 8

thymoma

Question 9

lambert-eaton

Answer 9

ab against the calcium channel in the presynaptic terminal
proximal muscles involved and eyes usually spared
typically a paraneoplastic syndrome related to small cell carcinoma
improves with use.

Question 10

What is the typical cell of liposcarcoma

Answer 10

lipoblast

Question 11

What is associated with a rhabdomyoma?

Answer 11

tuberous sclerosis

Question 12

What is one feature of rhabdomyosarcoma cells? what are the most common sites? how does patient influence that?

Answer 12

desmin positive rhabdomyoblast. most common site is the head and neck. seen in the vagina of young girls