quiz 3 disease pathogenesis and treatment

Question 1

tetanus pathogenesis

Answer 1

• tetanus toxin
• A and B unit, B binds and A is toxic
• neurons, effects GABA and glycine
• spastic paralysis

Question 2

tetanus treatment

Answer 2

• human anti-tetanus immunoglobulin (dirty wounds)
• penicillin
• wound debridement
• respiratory support
• immunization with tetanus toxoid (1 dose if immunized more than 5 years go, or complete course if never immunized)

Question 3

botulism pathogenesis

Answer 3

• botulism toxin
• A and B subunits, A is a protease
• A, B, E serotypes most common
• acetylcholine (flaccid paralysis)
• toxin is heat labile (100C for 10 mins)