Cholesterol

Question 1

What med causes the greatest reduction in TG?

Answer 1

Fibrates (20-50%)

Nicotinic acid also decreases TG 20-50%

Question 2

What med causes the greatest reduction in LDL?

Answer 2

Statins/HMG CoA reductase inhibitors (18-55%)

Bile acid sequestrants decrease LDL by 15-30%

Question 3

S/E and C/I of statin?

Answer 3

S/E: Myopathy, Increased liver enzymes

C/I:Active/chronic liver disease

Question 4

S/E and C/I of bile acid sequestrants?

Answer 4

S/E: GI distress, constipation

C/I:Dysbetalipoproteinemia, TG>400

Question 5

Which cholesterol med has no effect on TG (or increases it?)

Answer 5

Bile acid sequestrants (ie. cholestyramine)

Question 6

S/E and C/I of nicotinic acid?

Answer 6

S/E: flushing, hyperglycemia, hyperuricemia, upper GI distress, hepatotoxicity
C/I: Chronic liver disease, gout

Question 7

S/E and C/I of fibric acids?

Answer 7

S/E: dyspepsia, gallstones, myopathy

C/I: severe renal or hepatic disease, TG >200

Question 8

What is an optimal lipid profile?

Answer 8

Total <150