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IHO Week 1 > Krafts practice questions > Flashcards

Krafts practice questions Flashcards

1
Q

Anisocytosis refers to:
A.Proliferation of red cells B.Absence of red cells
C.Virtual absence!of hemoglobin in red cells
D.Variation in red cell size
E. Variation in red cell shape

A

D. Variation in red cell size

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2
Q

Your 28 year old, healthy sister was found to have a low hemoglobin when she tried to donate blood. Her doctor ordered a CBC, which showed the following:
Hgb 10g/dL(12N16) RBC!3.5x1012/L(4.5N6.0)
MCV75fL(80N100) WBC9.5x109/L(4N11)
RDW15%(12–13.5) Plt400x109/L(150N450)
What is the most likely cause of your sister’s anemia?
A. Thalassemia
B. Iron deficiency anemia
C. Hereditary spherocytosis
D. Aplastic anemia
E. Megaloblastic anemia

A

B. Iron deficiency anemia

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3
Q 
What is in a Heinz body?
A. Nuclear fragments 
B. Rough endoplasmic reticulum! C.Iron
D. Denatured globin chains 
E. Ketchup
A

D. Denatured globin chains

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4
Q

Malignancy, obstetric complications, sepsis and trauma can all cause which of the following findings on a blood smear?
A. Schistocytes
B. Oval macrocytes
C. Heinz bodies
D. Red blood cell agglutination E. Sickle cells

A

a schisto

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5
Q 
It’s hard to believe, but your next patient has an elevated basophil count. She should be evaluated to see if she has:
A. E.coli sepsis
B. Lupus
C. Stress
D. Drug reaction
E. Chronic myeloid leukemia
A

E. Chronic myeloid leukemia

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6
Q

Which of the following is true of acute leukemia?
A. Symptoms come on slowly, over a period of months or years.
B. The bone marrow and blood are full of mature lymphoid or myeloid cells.
C. It almost never occurs in adults.
D. If a child gets acute leukemia, it is most often of the myeloid lineage.
E. It is rapidly fatal if not treated immediately.

A

E. It is rapidly fatal if not treated immediately.

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7
Q

All of the following statements about leukemia are true EXCEPT:
A. Acute leukemias typically present with sudden-onset bone marrow failure.
B. Acute leukemias are composed of blasts, and chronic leukemias are composed of maturing cells.
C. A T-cell immunophenotype is a poor prognostic indicator in acute lymphoblastic leukemia.
D. Acute lymphoblastic leukemia is most common in adults.
E. Chronic leukemias have a prognosis on the order of many years.

A

D. Acute lymphoblastic leukemia is most common in adults.

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8
Q 
Patients with which of the following types of leukemia are at high risk for disseminated intravascular coagulation (DIC)?
A. Chronic myeloid leukemia
B. Chronic lymphocytic leukemia
C. Acute promyelocytic leukemia
D. Acute monoblastic leukemia
E. Acute erythroblastic leukemia
A

C. Acute promyelocytic leukemia

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9
Q 
You are treating a patient who is undergoing therapy for acute leukemia. He has diffuse, massive gingival enlargement. Which of the following cell types does his leukemia most likely involve? 
A. Neutrophil series
B. Monocytic series 
C. Erythroid series
D. Megakaryocytic series
E. Basophilic series
A

B. Monocytic series

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10
Q 
Which of the following disorders has a 20% cutoff for diagnosis?
A. Acute myeloid leukemia 
B. Acute lymphoblastic leukemia
C. Chronic myeloid leukemia
D. Chronic lymphocytic leukemia
E. Polycythemia vera
A

A. Acute myeloid leukemia

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11
Q 
Which of the following types of acute leukemia most frequently involves extra medullary sites?
A. Acute promyelocytic leukemia
B. Acute monoblastic leukemia
C. Acute erythroblastic leukemia
D. Acute megakaryoblastic leukemia
D. Acute lymphoblastic leukemia
A

B. Acute monoblastic leukemia

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12
Q 
If a child gets leukemia, more often than not it is usually which kind? 
A. Chronic myeloid leukemia
B. Chronic myelofibrosis
C. Chronic lymphocytic leukemia
D. Acute myeloid leukemia
E. Acute lymphoblastic leukemia
A

E. Acute lymphoblastic leukemia

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13
Q 
The Philadelphia chromosome is characteristic of which type of leukemia? 
A. Acute myeloid leukemia
B. T-cell acute lymphoblastic leukemia
C. Chronic lymphocytic leukemia
D. Chronic myeloid leukemia
E. Polycythemia vera
A

D. Chronic myeloid leukemia

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14
Q

A healthy, 58 year old male is found to have a mild lymphocytosis during a routine physical examination. All the lymphocytes appear small and mature, and immunophenotyping shows that they express both CD19 and CD5. What is the most likely diagnosis in this patient?
A. Benign, reactive lymphocytosis
B. Chronic lymphocytic leukemia/small lymphocytic lymphoma
C. B-cell acute lymphoblastic leukemia
D. T-cell acute lymphoblastic leukemia
E. Mycosis fungoides/ Sexary syndrome

A

B. Chronic lymphocytic leukemia/small lymphocytic lymphoma

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15
Q

A 60-year old male has blood smear showing a marked neutrophilic leukocytosis with a left shift and a basophilia. His marrow is hyper cellular and composed predominantly of neutrophilis and precursors. A cytogenetic assay of the neutrophils shows a translocation between chromosomes 9 and 22. Which of the following statements is true regarding his disease.
A. It has two phases
B. It is always rapidly progressive
C. It usually occurs in children
D. It may be benign
E. There is a chemotherapy drug called imatinib (Gleevec) that has improved survival greatly in most patients with this disease

A

E. There is a chemotherapy drug called imatinib (Gleevec) that has improved survival greatly in most patients with this disease

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16
Q

The four chronic myeloproliferative disorders:
A. Usually present with pancytopenia
B. May show splenomegaly
C. Occur just as often in children as they do in adults
D. Are indistinguishable from each other under the microscope
E. Are usually fatal within a period of months

A

B. May show splenomegaly

17
Q

All of the following are true of multiple myeloma EXCEPT:
A. There is a malignant proliferation of plasma cells in the bone marrow
B. A monoclonal gammopathy is present
C. Normal immunoglobulins are decreased
D. Patients have osteolytic lesions
E. Even without treatment, the clinical course is long, with a mean survival of 20+ years

A

E. Even without treatment, the clinical course is long, with a mean survival of 20+ years

18
Q 
What is the most commonly-expressed heavy chain in multiple myeloma?
A. lgA
B. lgD
C. leg
D. lgG
E. lgM
A

D. lgG

19
Q 
Tingible-body macrophages may be seen in:
A. Burkitt lymphoma
B. Benign germinal centers
C. Both
D. Neither
A

C. Both

20
Q 
A 68 year old male has large, scaly, red plaques on his back and buttocks. A skin biopsy shows small abscess-like spaces in the dermis, filled with cerebriform lymphocytes. His blood contains the same cells, which on immunophenotyping display T-cell markers. What is the most likely diagnosis?
A. Small lymphocytic lymphoma
B. T-cell acute lymphoblastic lymphoma
C. Diffuse large cell lymphoma
D. Mycosis fungoides/Sezary syndrome
E. Burkitt lymphoma
A

D. Mycosis fungoides/Sezary syndrome

IHO Week 1 (7 decks)

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