Haematology

Question 0

How long does it take for warfarin to become active?

Answer 0

At least 48hrs

Question 1

How does warfarin work?

Answer 1

1. Rapidly depletes hepatic vitamin K by impairing its recycling
2. Prevents synthesis of vitamin K dependent factors II, VII, IX, X

Question 2

Is protein c vitamin k dependent?

Answer 2

Yes

Question 3

What does protein c do?

Answer 3

Inactivates active forms of pro coagulant factors Va and VIIIa

Question 4

What is haemophilia A?

Answer 4

1. Factor VIII deficiency

Question 5

What is haemophilia B?

Answer 5

Factor IX deficiency

Question 6

Where is serotonin stored?

Answer 6

Platelets

Question 7

What does serotonin do when released from platelets?

Answer 7

Vasoconstrictor

Question 8

Factor V Leiden mutation

Answer 8

5% population

Question 9

Hypogammaglobulinaemia

Answer 9

Infections with haemophillus influenza and Streptococcus pneumonia

Question 10

T-cell deficiencies

Answer 10

Streptococcus pyogenes
Pneumocystis jiroveci
Viral
Candida

Question 11

Raised MCV

Answer 11

Megaloblastic anaemias
Red cell membrane disorders
Alcohol

Question 12

Haemophilia

Answer 12

APTT - increased
PT - normal
Bleeding time - normal

Question 13

von Willebrands disease

Answer 13

APTT increased
PT normal
Bleeding time - increased

Question 14

Vitamin K deficiency

Answer 14

APTT - increased
PT - increased
Bleeding time - normal