Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PHARM 203 > 25: Antidepressants > Flashcards

25: Antidepressants Flashcards

(53 cards)

Start Studying
1
Q

MAO theory

A 
depression = lacks NE and 5HT
mania = too much
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

TCA action

A

blocks NE and 5HT reuptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MAOI action

A

increases NE and 5HT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

reserpine action

A

inhibits NE and 5HT storage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

alpha methyl tyrosine and methyldopa action

A

inhibits NE synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

ECT

A

increases CNS responses to NE and 5HT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

tryptophan action

A

increases 5HT synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

issues with MAO theory

A

drect neurochemical effects appear rapidly, but antidepressant effects take weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

neuroendocrine mechanisms of depression

A

HPA axis

  • NE and 5HT inputs
  • in depressed pts: CRH - ACTH - cortisol release
  • decrease in GH and increase in prolactin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

trophic effects and neuroplasticity of depression

A

decrease levels of BDNF
increase Glu = excitotoxicity
neuronal loss in hippocampus and prefrontal cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

list inhibitors of MAO reuptake

A 
SSRIs
NDRIs
SNRIs
TCAs
St. John's wort
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MAOIs list

A

irreversible, noncompetitive, nonselective- MAOA and MAOB

reversible = MAOA selective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SARI

A

serotonin-2 antagonists/ serotonin reuptake inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

serotonin ___ agonist/ serotonin reuptake inhibitor

A

1A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

NaSSA

A

noradrenergic/ specific serotonergic agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

bupropion is a

A

NA reuptake inhibitor- NDRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

trazodone is a

A

5HT reuptake inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

NE reuptake blockade effect

A

antidepressant

side effects: tremors, tachycardia, hypertension, sweating, erectile and ejaculation problems

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

5HT reuptake blockade effects

A

antidepressant, antianxiety, antipanic, antiobsessional effect

side effects: dyspepsia, nausea, headache, sexual
serotonin syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

DA reuptake blockade affect

A

mitigates against prolactin elevation

may aggravate psychosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

5HT1A agonism effect

A

antidepressant, anxiolytic, antiaggressive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

5HT2A blockade

Study These Flashcards
A

anxiolytic, antidepressant, antipsychotic, antimigraine, improved sleep
side effects: hypotension, ejaculatory problems, sedation, weight gain

23
Q

M1 blockade effects

Study These Flashcards
A

dry mouth, blurred vision, anticholinergic effects

- second most potent action of TCAs

24
Q

TCAs actions in order of potency

Study These Flashcards
A
  1. H1 blockage
  2. ACh M1 blockage
  3. NA
  4. 5HT
25
H1 blockade effects
sedation, postural hypotension
26
alpha 1 blockade effects
postural hypotension, dizziness, reflex tachycardia | potentiation of antihypertensive drugs
27
alpha 2 blockade effects
possible decrease in depressive symptoms
28
D2 blockade effect
antipsychotic
29
paroxetine, sertraline, citalopram, and escitalopram are
SSRIs
30
SSRIs in addition to their normal function, also
inhibit NE and DA reuptake
31
what drug has risk of QT interval prolongation
citalopram
32
what is the most obvious SSRI adverse reaction
enhanced 5HT levels = risk of serotonin syndrome
33
TCA actions
NE and 5HT reuptake inhibitors that vary in selectivity and activity also affect H1 and ACh blockage
34
secondary amine TCA action
NE > 5HT
35
desipramine and nortriptyline are
secondary amine TCAs
36
amitriptyline, clomipramine, doxepin, imipramine, trimipramine are
tertiary amine TCAs
37
tertiary amine TCAseffect
increased 5HT effect but still more inhibition of NA reuptake
38
how do TCAs cause orthostatic hypotension
blocking alpha receptors
39
what SNRI targets 5HT at low doses and NE at high doses
venlafaxine
40
which has fewer side effects, TCA or SNRIs
SNRIs
41
what is bupropion
NDRI
42
what lowers seizure thresholds
NDRIs | bupropion
43
trazodone is a
SARI
44
trazodone action
blocks 5HT 2A and 2C receptors | blocks 5HT reuptake
45
mirtazapine is a
NaSSA
46
what does mirtazapine block
alpha2 adrenoceptors 5HT2A 5HT2C 5HT3
47
what side effects does mirtazapine have
antihistamine side effects as it is a potent H1 receptor antagonist
48
vortioxetine
serotonin modulator and sitmulator
49
vilazodone
serotonin 1A agonist/ serotonin reuptake inhibitor
50
what is the main target for antidepressant MAOIs
MAOA
51
phenelzine and tranylcypromine are examples of
irreversible, noncompetitive nonselective inhibitors
52
moclobemide is a
reversible, MAO-A selective inhibitor
53
why is MAOI an last resort drug
hypertensive crisis can be triggered by tyramine- lots of food restrictions + OTC cough and cold agents can contain sympathomimetics

PHARM 203 (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions