25 - New Approach Methodologies

Question 1

New Approach Methodologies include:

Answer 1

1. In silico
2. In chemico
3. In vitro
4. CFSAN

Question 2

Computational Recognition of Chemical Structures: Descriptors

Answer 2

1. ABCindex
2. ACID/BASE
3. Adjacency matrix
4. Aromatic etc.

Question 3

QSAR: Quantitative Structure Activity Relationships

Answer 3

They examined several multilinear regression models predicting biological activity

Question 4

5 OECD Principles for validation of QSAR for regulatory purposes

Answer 4

1. Defined endpoint
2. Unamibgious algo. (reproducible)
3. Domain of applicability
4. Goodness of fit
5. Mechanistic interpretation